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Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. ContributorsM. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang

Table of Contents

  1. Cover
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  1. Half Title, Series Info, Title Page, Copyright
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  1. Contents
  2. pp. v-vi
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  1. The Ernst Strüngmann Forum
  2. pp. vii-viii
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  1. List of Contributors
  2. pp. ix-xii
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  1. 1. Introduction
  2. Jerome O. Nriagu, Eric P. Skaar
  3. pp. 1-10
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  1. Host–Microbe Interactions: The Microbe Perspective
  1. 2. Is Metal Uptake Related to Ecological Niche in the Vertebrate Host?
  2. Joseph Lemire, Trevor F. Moraes, Vahid Fa Andisi, Anthony B. Schryvers
  3. pp. 13-28
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  1. 3. Competition for Metals among Microbes and Their Host
  2. Michael A. Bachman, Jeffrey N. Weiser
  3. pp. 29-38
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  1. 4. The Fate of Intracellular Metal Ions in Microbes
  2. Slade A. Loutet, Anson C. K. Chan, Marek J. Kobylarz, Meghan M. Verstraete, Stephanie Pfaffen, Bin Ye, Angel L. Arrieta, Michael E. P. Murphy
  3. pp. 39-56
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  1. 5. Common Mechanisms of Bacterial Metal Homeostasis
  2. James A. Imlay
  3. pp. 57-82
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  1. 6. Intervention Strategies for Metal Deficiency and Overload
  2. Audi Wang, Lihong Zhang
  3. pp. 83-98
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  1. 7. Trace Metals in Host–Microbe Interactions: The Microbe Perspective
  2. Jennifer S. Cavet, Robert D. Perry, Sascha Brunke, K. Heran Darwin, Carol A. Fierke, James A. Imlay, Michael E. P. Murphy, Anthony B. Schryvers, Dennis J. Thiele, Jeffrey N. Weiser
  3. pp. 99-122
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  1. Host–Microbe Interactions: The Host Perspective
  1. 8. Metal Homeostasis during Development, Maturation, and Aging: Impact on Infectious Diseases
  2. Inga Wessels
  3. pp. 125-146
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  1. 9. Impact of Metals on Immune Response and Tolerance, and Modulation of Metal Metabolism during Infection
  2. Günter Weiss
  3. pp. 147-160
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  1. 10. Metal-Based Antiparasitic Therapeutics
  2. Maribel Navarro, Gonzalo Visbal
  3. pp. 161-172
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  1. 11. Impact of Lifestyle on Metal Exposure, Homeostasis, and Associated Diseases
  2. George V. Dedoussis
  3. pp. 173-184
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  1. 12. Obesity, Trace Metals, and Infection
  2. Jerome O. Nriagu
  3. pp. 185-198
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  1. 13. Metals in Host–Microbe Interaction: The Host Perspective
  2. Dieter Rehder, Robert E. Black, Julia Bornhorst, Rodney R. Dietert, Victor J. DiRita, Maribel Navarro, Robert D. Perry, Lothar Rink, Eric P. Skaar, Miguel C. P. Soares, Dennis J. Thiele, Fudi Wang, Günter Weiss, Inga Wessels
  3. pp. 199-226
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  1. Metals in the Environment as Risk Factors for Infectious Diseases
  1. 14. Selenium and Mercury: Their Interactions and Roles in Living Organisms
  2. Tamara García-Barrera
  3. pp. 229-238
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  1. 15. New Technologies Using Trace Metals of Concern
  2. Jozef M. Pacyna, Kyrre Sundseth, Elisabeth G. Pacyna
  3. pp. 239-256
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  1. 16. The Promise of Nanometers: Reducing Infection and Increasing Biocompatibility
  2. Mian Wang, Wenwen Liu, Thomas J. Webster
  3. pp. 257-270
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  1. 17. Metals in the Environment as Risk Factors for Infectious Diseases: Gaps and Opportunities
  2. M. Leigh Ackland, Julia Bornhorst, George V. Dedoussis, Rodney R. Dietert, Jerome O. Nriagu, Jozef M. Pacyna, John M. Pettifor
  3. pp. 271-308
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  1. Methods and Technologies for Analyzing Trace Metals in Biological Systems
  1. 18. Emerging Strategies in Metalloproteomics
  2. Peter-Leon Hagedoorn
  3. pp. 311-322
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  1. 19. Measuring Metals in Complex Biological Systems
  2. Andreas Matusch, Ana-Maria Oros-Peusquens, J. Sabine Becker
  3. pp. 323-340
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  1. 20. Methods and Technologies for Studying Metals in Biological Systems
  2. Wolfgang Maret, Joseph A. Caruso, Christopher H. Contag, David P. Giedroc, Peter-Leon Hagedoorn, Andreas Matusch, Eric P. Skaar, Richard B. Thompson
  3. pp. 341-402
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  1. List of Acronyms
  2. pp. 403-406
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  1. Bibliography
  2. pp. 407-476
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  1. Subject Index
  2. pp. 477-488
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Additional Information

ISBN
9780262327619
Related ISBN
9780262029193
MARC Record
OCLC
910513394
Pages
504
Launched on MUSE
2017-01-01
Language
English
Open Access
No
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