Taking up Paul Preciado's theories in his book Testo Junkie (2013) concerning contemporary biocapitalism, this essay argues that Michel Houellebecq's latest novel, Sérotonine (2019), represents a radical move away from the hegemony of the white cis-male, heterosexual body depicted in his earlier literary corpus. The narrator of Sérotonine is stripped of his sexual capacity by an antidepressant that makes him impotent. Once unable to escape the stimuli and commodities designed to incite pleasure, thus leaving the body in a constant state of arousal, Houellebecq's male subject is now unequivocally portrayed as being flaccid. Rather than disclose a sense of reconciliation or resignation with the market, the novel reveals an expulsion from it entirely. The narrator's futile attempts to reinstate his male dominance further demonstrate the totalizing presence of sex, pleasure, and pharmaceutical drugs in Houellebecq's novels and attest to the notion that the once-hegemonic male body of his literary universe is now simply hanging on to life itself as contemporary biocapitalism careens forward on its never-ending quest to maximize pleasure and desire.