Project MUSE - Cases in Bioethics: Health Research Ethics in Southeast Asia

Effect of Mutations in Atrial Septal Defect Patients

Roslina Husaini, Nur Liana Md Nasir, Norizan Rosli

Keywords: heart disease, research misconduct, data use, genetics/genomics, liability

DOI: https://doi.org/10.1353/resource5.case0

Unauthorized Use of Lab Equipment for Research Purposes

Roslina Husaini, Nur Liana Md Nasir, Norizan Rosli

Keywords: cancer treatment, unauthorized use of equipment, research misconduct, laboratory research

DOI: https://doi.org/10.1353/resource5.case1

Rights and Protections for Clinical Research Staff

Norizan Rosli, Nur Ain Zahidah

Keywords: employee rights, research staff, compensation/remuneration, research integrity, responsible conduct of research

DOI: https://doi.org/10.1353/resource5.case2

Comparing Two Drugs to Prevent Postpartum Hemorrhage

Siti Fatimah Zahra Mohd Anuar, Fatihah Mahmud, Norizan Rosli

Keywords: postpartum hemorrhage, maternal mortality, high-risk pregnant women, randomized double-blind clinical trial, informed consent, return of findings

DOI: https://doi.org/10.1353/resource5.case3

Evaluation of a Minimal Risk Research Protocol by a Research Ethics Subcommittee

Nur Khairul Bariyyah Mohd Hatta, Lai Wei Hong, Norizan Rosli

Keywords: research ethics committees, ethical review, minimal risk research, anonymity, quality improvement/assurance

DOI: https://doi.org/10.1353/resource5.case4

Reconsent for Biobanking During a Pandemic

Tiong Xun Ting, Siti Nur Syahirah Morshidi, Lai Wei Hong Lai, Shirin Tan Hui, Hans Prakash Sathasivam

Keywords: biobanking, COVID-19 pandemic, informed consent, reconsent, remote consent, waiver of consent

DOI: https://doi.org/10.1353/resource5.case5

Private Cord Blood Stem Cell Banking

Mohammad Firdaus Bin Abdul Aziz, Nishakanthi Gopalan, Kee Seong Ng, Phang Kean Chang, Kuen Yei Chin

Keywords: consent, conflict of interest, cord blood, regenerative medicine, biobanking, pregnancy

DOI: https://doi.org/10.1353/resource5.case6

Genetic Material Sampling from an Indigenous Community

Yi Xian Er, Kuen Yei Chin, Mohammad Firdaus Abdul Aziz, Kee Seong Ng

Keywords: Indigenous people, skin disease, genetic sampling, biological samples, exploratory study, consent, blanket consent, assent, cultural competency, community engagement, return of results

DOI: https://doi.org/10.1353/resource5.case7

Scaling Up HIV Self-Testing in a Heterogeneous Setting

Teong Win Zee, Rumana Saifi

Keywords: research design, justice, stigma, HIV, online service delivery, pilot study using rapid HIV test kit, key population, HIV

DOI: https://doi.org/10.1353/resource5.case8

An HIV Self-Testing Intervention to Promote HIV Testing among Key Populations

Teong Win Zee, Rumana Saifi

Keywords: stigma, discrimination, justice, risk management, participant selection, HIV, online survey, feasibility of HIV self-testing and service delivery, local volunteers (18 years or older), HIV-negative or unknown status

DOI: https://doi.org/10.1353/resource5.case9

Accessing a Novel Cancer Therapy

Ch'ng Wan Ping

Keywords: consent, participation information sheet (PIS), conflict of interest, immunotherapy, breast cancer, clinical trial, breast cancer patients

DOI: https://doi.org/10.1353/resource5.case10

Musculoskeletal Steroid Injection for Pain Management during COVID-19

Azwan Aziz, Azmi Mohamad Nahar

Keywords: sports medicine, steroid injections, privacy, confidentiality, public health data, consent, COVID-19, records review, musculoskeletal steroid injection patients

DOI: https://doi.org/10.1353/resource5.case11

A Cross-Sectional Study of the Impact of Online Dental Education during the Pandemic

Anand Marya

Keywords: education research, online learning, COVID-19, survey, study design, student participants, IRB review, dentistry degree students in Cambodia

DOI: https://doi.org/10.1353/resource5.case12

A Prospective Study on Immune Response of a COVID-19 Vaccine Booster

Robert Sinto

Keywords: vaccines; boosters; genetics; consent, COVID-19, ethics review, health care workers

DOI: https://doi.org/10.1353/resource5.case13

Investigating Opinions on Emerging Science and Technology

Angelina Olesen

Keywords: deception, respect for persons, consent, stigma, preimplantation diagnosis (PGD), qualitative research, Southeast Asian women

DOI: https://doi.org/10.1353/resource5.case14

Newborn Screening for Detection of Inherited Diseases

Ebner Bon G. Maceda, Mary Ann R. Abacan, Mary Anne D. Chiong, Catherine Lynn T. Silao, Maria Melanie Liberty B. Alcausin

Keywords: consent, assent, confidentiality, fatty acid oxidation, genetics, biobanking, screening, newborns, children

DOI: https://doi.org/10.1353/resource5.case15

Lottery Incentives in HIV Research

Alex Phang Kean Chang

Keywords: incentive, inducement, lottery, HIV, social media, HIV, PrEP, MSM

DOI: https://doi.org/10.1353/resource5.case16

Welfare of Researchers in an Infectious Disease Study

Alex Phang Kean Chang

Keywords: compensation for research-related injury, risk management, infection control, incentives, COVID-19, interviews and data collection, study staff

DOI: https://doi.org/10.1353/resource5.case17

Reproductive and Mental Health in Female Refugees

Wan Rosalina Wan Rosli

Keywords: informed consent, ethics review, individual and collective risk, mental health, reproductive health, community-based research, community engagement, refugees, vulnerability

DOI: https://doi.org/10.1353/resource5.case18

Dietary Supplementation for Prepubertal Children in Urban Public Schools

Erwin Jiayuan Khoo, Winnie Siew Swee Chee

Keywords: vulnerability, assent, inducements, nutrition, clinical trial, minors

DOI: https://doi.org/10.1353/resource5.case19

Manufacturing Reliable Rapid Antibody Test Kits for the Investigation of Infectious Diseases

Erwin Khoo

Keywords: consent, privacy, confidentiality, social value, dengue diagnosis, rapid tests, reuse of blood samples, dengue patients with positive antibody

DOI: https://doi.org/10.1353/resource5.case20

Conducting a Vaccine Trial with Adolescents during a Pandemic

Chong Lee Ai

Keywords: COVID-19, vaccines, adolescents, trial design, randomization, risks, benefits, monitoring, equipoise, standard of care, clinical trial, recruitment, consent

DOI: https://doi.org/10.1353/resource5.case21

Strengthening the Legal and Regulatory Framework for Research Involving Biobanks in Malaysia

Amnah Azahar, Hafizah Zainal Abidin, Aimi Nadia Mohd Yusof

Keywords: consent, vulnerability, return of findings, independent review, stigma, biobanking, policy analysis, policymakers

DOI: https://doi.org/10.1353/resource5.case22

Asthma Research in the Emergency Department

Hafizah Binti Zainal Abidin, Amnah binti Azahar

Keywords: informed consent, retrospective consent, emergency medicine, asthma, waiver, emergency medicine

DOI: https://doi.org/10.1353/resource5.case23

Testing a Wobble Board for Fall Prevention in Older People

Mei Lian Leow, Phei Ming Chern

Keywords: device research, risks, safety, insurance, device research, home-based research, home-based research, elderly population

DOI: https://doi.org/10.1353/resource5.case24

Conducting Research with People Who Inject Drugs during the COVID-19 Pandemic

Nur Afiqah Mohd Salleh

Keywords: pandemic, privacy, confidentiality, duty of care, ancillary care, substance use, HIV prevalence, qualitative interviews, virtual data collection, people who inject drugs (PWID)

DOI: https://doi.org/10.1353/resource5.case25

A Clinical Trial to Compare Orthodontic Retainers

Wan Nurazreena Wan Hassan, Norhidayah Mohd Tahir

Keywords: study design, washout period, orthodontics, clinical trial, people who wear braces/retainers

DOI: https://doi.org/10.1353/resource5.case26

Co-enrollment of Patients in Research Involving Tissue Collection

Maylene Tan Zipagan

Keywords: co-enrollment, consent, recruitment, safety, burden, OB/GYN, Tissue sampling, patients, OB/GYN

DOI: https://doi.org/10.1353/resource5.case27

Designing an mHealth App for HIV Prevention

Jeffrey Ralph B Luces, Rumana Akhter Saifi

Keywords: consent, vulnerable population, stigma, privacy, legal risk, HIV prevention, mobile health, qualitative research, MSM

DOI: https://doi.org/10.1353/resource5.case28

Permission and Assent for Research with Children Who Have Cerebral Palsy

Leow Mei Lian, Phei Ming Chern

Keywords: vulnerable population, assent, protocol amendments, consent, cerebral palsy, two-phase study, questionnaire, children with cerebral palsy

DOI: https://doi.org/10.1353/resource5.case29

Role of BRCA1 and BRCA 2 in Hereditary Breast Cancer Risk

Sok-Kun Tae, Meow-Keong Thong, Rifhan Azwani Mazlan

Keywords: consent, return of results, incidental findings, cancer, biobanking, genetics, patients

DOI: https://doi.org/10.1353/resource5.case30

Returning Cancer Genomic Research Results to Participants

Meow-Keong Thong, Sok-Kun Tae, Rifhan Azwani Mazlan

Keywords: return of results, confidentiality, research ethics committees, cancer, genetic testing, cancer patients, family members

DOI: https://doi.org/10.1353/resource5.case31

Research Involving Pregnant Adolescents in Southeast Asia

Aimi Nadia Mohd Yusof, Amirah Abdul Rahman, Thuhairah Hasrah, Abdul Rahman, Suraya Abdul Razak

Keywords: vulnerability; local oversight; multinational research; collaborative partnerships; consent; parent/guardian permission; privacy, adolescent pregnancy, qualitative interviews, adolescents

DOI: https://doi.org/10.1353/resource5.case32

Patient Perceptions of Privacy During Behavioral Monitoring in Psychiatric Wards

Nasriah Zakaria, Rusyaizila Ramli

Keywords: privacy, video monitoring, consent, participant selection, psychiatric research, qualitative research, mentally unstable patients

DOI: https://doi.org/10.1353/resource5.case33

Biobanking of Specimens from Children

Hans Prakash Sathasivam

Keywords: consent, assent, reconsent, rare diseases, biobanking, children

DOI: https://doi.org/10.1353/resource5.case34

Challenges with Tooth Donations for Research

Lim Ghee Seong, Hayati Ishak, Arilatha Arimuthu

Keywords: consent, autonomy, tooth donation, dental stem cell, qualitative survey, preclinical dental student

DOI: https://doi.org/10.1353/resource5.case35

Supplementing Micronutrients in Children under 3 Years Old

Chong Lee Ai

Keywords: incentives, placebo, nutrition, randomized controlled trial, children

DOI: https://doi.org/10.1353/resource5.case36

A Weight Reduction Intervention for Adolescent Students

Roli Mathur, Manikandan S

Keywords: stigma, vulnerable population, obesity, educational intervention, children; school-based study

DOI: https://doi.org/10.1353/resource5.case37

Drug Use and Risk of HIV and Other Blood-Borne Infections among Climate-Induced Migrants

Kaveh Khoshnood, Laura Bothwell

Keywords: stigma, vulnerable population, social harm, substance use, HIV prevalence, qualitative interviews, pilot study, migrants

DOI: https://doi.org/10.1353/resource5.case38

Delivery of Preexposure Prophylaxis (PrEP) for Men Who Have Sex with Men

Iskandar Shah Raja Azwa, Rumana Akhter Saifi

Keywords: stigma, social risk, study design, posttrial obligations, HIV/AIDS, MSM, open-label single arm pilot study, HIV, and MSM

DOI: https://doi.org/10.1353/resource5.case39

Managing Bruxism in Children with Cerebral Palsy

Ilham Wan Mokhtar

Keywords: consent, assent, vulnerability, dentistry, cerebral palsy, study design, randomized control trial, children, control groups

DOI: https://doi.org/10.1353/resource5.case40

Breach Of Confidentiality via Social Media

Suzita Mohd Noor, Rozaida Poh Yuen Ying

Keywords: privacy, confidentiality, studying hormone levels in female, depression, and anxiety, biospecimen collection, blood, volunteers with history of depression and anxiety

DOI: https://doi.org/10.1353/resource5.case41

Pregnant Women as Research Participants: a Study on HPV Self-Sampling

Ch'ng Wan Ping, Rumana Saifi

Keywords: research involving pregnant women, vulnerable population, consent, posttrial obligations, HPV screening study, field trial, 27-weeks pregnant women

DOI: https://doi.org/10.1353/resource5.case42

A Remote Survey of HPV Stigma during the COVID-19 Pandemic

Ch'ng Wan Ping, Rumana Saifi

Keywords: remote research, virtual research, social media, stigma, privacy, confidentiality, consent, deception, views and attitude on HPV, online survey, health care providers

DOI: https://doi.org/10.1353/resource5.case43

Clinical Trial of a Novel Therapeutic with Critically Ill Patients during a Pandemic

Ch'ng Wan Ping

Keywords: standard of care, vulnerability, impaired decision-making, consent, therapeutic misconception, COVID-19, open-label trial, critically ill COVID-19 patients

DOI: https://doi.org/10.1353/resource5.case44

Awareness, Knowledge, Attitudes, and Use of E-Cigarettes in School-Aged Children

Nor Adinar Baharuddin

Keywords: privacy, confidentiality, consent, assent, children, return of results and study findings, computer-based research, children

DOI: https://doi.org/10.1353/resource5.case45

Conducting School-Based Mental Health Research

Hu Mi, Esther Luo, Laura Bothwell, Kaveh Khoshnood

Keywords: stigma, vulnerable population, risk management, return of findings, mental health, epidemiology, children, school-based study

DOI: https://doi.org/10.1353/resource5.case46

Health Professionals’ Perspectives on Counseling Patients about Congenital Disorders and Abortion

Dan Luo, Yanlin Liu, Esther Luo, Laura Bothwell, Kaveh Khoshnood

Keywords: stigma, vulnerable population, abortion, value conflicts, congenital disorders, qualitative interviews, clinicians

DOI: https://doi.org/10.1353/resource5.case47

Stigma in Health Care Settings Experienced by Key Populations

Asfarina Amir Hassan, Rumana Saifi, Wong Pui Li, Valerie Earnshaw

Keywords: stigma, vulnerable population, privacy, HIV, online focus group discussions, clinicians, medical students, nursing students

DOI: https://doi.org/10.1353/resource5.case48

An International Industry-Sponsored Trial to Prolong Life Expectancy of Liver Failure Patients

Harnawan Rizki, Chin Kuen Yei, Ch’ng Wan Ping, Rumana Saifi

Keywords: justice, risk-benefit, multinational industry-sponsored research, payment, researcher responsibilities, cell regeneration study, biosample collection, patients with liver damage

DOI: https://doi.org/10.1353/resource5.case49

Studying the Impact of the COVID-19 Pandemic on the Rohingya Community in Kuala Lumpur

Raudah Mohd Yunus, Chen Xin Wee, Ely Zarina Samsudin, Aimi Nadia Mat Ruzlin

Keywords: vulnerable populations, research design, informed consent, justice, incentives, COVID-19 impact, qualitative study, refugee and asylum seekers, Rohingya

DOI: https://doi.org/10.1353/resource5.case50

Fair Sharing of Benefits in Research Involving Human Biological Materials

Chin Kuen Yei, Harnawan Rizki, Rumana Akhter Saifi

Keywords: international collaboration, biobanking, benefit sharing, commercialization, informed consent, hepatitis C treatment and prevention, liver cell regeneration, vaccine research, biospecimen storage, patients with liver disease

DOI: https://doi.org/10.1353/resource5.case51

Integrating Research Ethics into an Undergraduate Medical Curriculum

Lui Sze Chiang, Rumana Saifi

Keywords: ethics approval, ethics oversight, student research, survey research, adolescents, Indigenous populations

DOI: https://doi.org/10.1353/resource5.case52

Continued Access to Treatment for Patients Withdrawing from Clinical Trials

Nishakanthi Gopalan, Julia Patrick Engakasan, Tivyashinee, Phan Chia Wei

Keywords: duty of care, voluntariness, breast cancer, interventional study, risk communication

DOI: https://doi.org/10.1353/resource5.case53

Prevalence of Military Sexual Trauma among Military Personnel

Hong Chuan Loh, Chirk Jenn Ng

Keywords: stigma, privacy, confidentiality, risk, captive population, sexual minorities, sexual trauma, military, cross-sectional study, vulnerability, dissemination

DOI: https://doi.org/10.1353/resource5.case54

A Clinical Trial Involving People with Memory Impairments

Julia Patrick Engkasan, Mazlina Mazlan, Nishakanthi Gopalan, Tivyashinee

Keywords: brain injury, consent, surrogate decision-making, autonomy, respect for persons, justice, rehabilitation, clinical trial, inclusion

DOI: https://doi.org/10.1353/resource5.case55

Permission and Assent among Children during Clinical Research

Lui Sze Chiang, Azanna Ahmad Kamar, Nishakanthi Gopalan, Asiah Kassim

Keywords: privacy, confidentiality, consent, assent, permission, undue influence, best interests, qualitative research, COVID-19, qualitative research, decision-making

DOI: https://doi.org/10.1353/resource5.case56

Human Biobanking Research in Low- and Middle-Income Countries

Kuen Yei Chin, Mohammad Firdaus Abdul Aziz, Kee Seong Ng, Yi Xian Er, Charles Li Qi Gunn

Keywords: consent, authorship, Indigenous peoples, genetics/genomics, biobanking, malaria research, international collaboration, secondary use, gatekeepers, national research ethics committee

DOI: https://doi.org/10.1353/resource5.case57

Better Mice in Corridors Than Mice in the Rooms!

Suzita Mohd Noor, Durriyyah Sharifah Hasan Adli

Keywords: animal ethics, research integrity, mice, protocol fidelity, institutional animal care and use committee (IACUC)

DOI: https://doi.org/10.1353/resource5.case58

Awareness of Animal Welfare

Suzita Mohd Noor, Durriyyah Sharifah Hasan Adli

Keywords: animal care and use, research integrity, reporting misconduct, animal research, student research, blood draws, animals

DOI: https://doi.org/10.1353/resource5.case59

A Randomized Study of Prison-Based Methadone Maintenance Therapy

Rumana Akhter Saifi

Keywords: prison research, privacy, confidentiality, coercion, consent, randomization, control groups, recruitment, safety, drug use, HIV, randomized trial, prisoners, people who use drugs

DOI: https://doi.org/10.1353/resource5.case60

Stability of Postorthodontic Treatment in Patients with Bimaxillary Proclination

Norhidayah Mohd Tahir, Wan Nurazreena Wan Hassan

Keywords: adverse event, risk, benefit, bimaxillary proclination treatment, randomized trial, posttreatment stability, patients who underwent bimaxillary proclination treatment

DOI: https://doi.org/10.1353/resource5.case61

A Qualitative Study of Stimulant-Using Men Who Have Sex with Men

Howie Lim Sin How

Keywords: HIV, STI, safety, stigma, stimulants, mental health, qualitative research, recruitment, MSM, social media, risks

DOI: https://doi.org/10.1353/resource5.case62

DOI	10.1353/resource.5
Launched on MUSE	2024-10-19
Open Access	Yes
Creative Commons	CC-BY-NC-ND

Cases in Bioethics: Health Research Ethics in Southeast Asia

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