Gender differences in the development and function of the immune system
RS Shames - Journal of Adolescent Health, 2002 - jahonline.org
Clinical and experimental evidence supports the hypothesis that sex and hypothalamic-
pituitary hormones affect the prevalence, severity, and natural history of immunologic
diseases [1–5]. Gender biases in the susceptibility to, and severity of, autoimmune and
allergic diseases are well-recognized. Many of these differences become apparent after
puberty. Animal models of autoimmunity and in vitro studies of human lymphoid cells also
demonstrate gender differences in immune function. These clinical and experimental …
pituitary hormones affect the prevalence, severity, and natural history of immunologic
diseases [1–5]. Gender biases in the susceptibility to, and severity of, autoimmune and
allergic diseases are well-recognized. Many of these differences become apparent after
puberty. Animal models of autoimmunity and in vitro studies of human lymphoid cells also
demonstrate gender differences in immune function. These clinical and experimental …