Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis
N Risch, R Herrell, T Lehner, KY Liang, L Eaves, J Hoh… - Jama, 2009 - jamanetwork.com
Context Substantial resources are being devoted to identify candidate genes for complex
mental and behavioral disorders through inclusion of environmental exposures following the
report of an interaction between the serotonin transporter linked polymorphic region (5-
HTTLPR) and stressful life events on an increased risk of major depression. Objective To
conduct a meta-analysis of the interaction between the serotonin transporter gene and
stressful life events on depression using both published data and individual-level original …
mental and behavioral disorders through inclusion of environmental exposures following the
report of an interaction between the serotonin transporter linked polymorphic region (5-
HTTLPR) and stressful life events on an increased risk of major depression. Objective To
conduct a meta-analysis of the interaction between the serotonin transporter gene and
stressful life events on depression using both published data and individual-level original …