In accordance with recent mechanistic advances, we recommend an applied, broad-based two-phase approach to limit inactivity-mediated losses of muscle mass and function in older adults:(i) Lifestyle: consume a moderate amount (25–30 g) of high-quality protein with each meal and incorporate habitual exercise in close temporal proximity to protein-containing meals;(ii) Crises: react aggressively to combat the accelerated loss of muscle mass and function during acute catabolic crises and periods of reduced physical activity. As a base strategy, this should include nutritional support such as targeted protein or amino acid supplementation and integrated physical therapy.