Adjunctive corticosteroids for Pneumocystis jiroveci pneumonia in patients with HIV-infection.
M Briel, HC Bucher, R Boscacci… - The Cochrane database of …, 2006 - europepmc.org
M Briel, HC Bucher, R Boscacci, H Furrer
The Cochrane database of systematic reviews, 2006•europepmc.orgBackground Pneumocystis jiroveci pneumonia (PCP) remains the most common
opportunistic infection in patients infected with the human immunodeficiency virus (HIV).
Among patients with HIV infection and PCP the mortality rate is 10 to 20% during the initial
infection and increases substantially with the need for mechanical ventilation. It was
suggested that in these patients corticosteroids adjunctive to standard treatment for PCP
could prevent the need for mechanical ventilation and decrease mortality. Objectives To …
opportunistic infection in patients infected with the human immunodeficiency virus (HIV).
Among patients with HIV infection and PCP the mortality rate is 10 to 20% during the initial
infection and increases substantially with the need for mechanical ventilation. It was
suggested that in these patients corticosteroids adjunctive to standard treatment for PCP
could prevent the need for mechanical ventilation and decrease mortality. Objectives To …
Background
Pneumocystis jiroveci pneumonia (PCP) remains the most common opportunistic infection in patients infected with the human immunodeficiency virus (HIV). Among patients with HIV infection and PCP the mortality rate is 10 to 20% during the initial infection and increases substantially with the need for mechanical ventilation. It was suggested that in these patients corticosteroids adjunctive to standard treatment for PCP could prevent the need for mechanical ventilation and decrease mortality.
Objectives
To assess the effects of adjunctive corticosteroids on overall mortality and the need for mechanical ventilation in HIV-infected patients with PCP and substantial hypoxemia (arterial oxygen partial pressure< 70 mmHg or alveolar-arterial gradient> 35 mmHg on room air).
europepmc.org