Mutational analysis of Pneumocystis jirovecii dihydropteroate synthase and dihydrofolate reductase genes in HIV-infected patients in China
X Deng, L Zhuo, Y Lan, Z Dai, W Chen… - Journal of clinical …, 2014 - Am Soc Microbiol
X Deng, L Zhuo, Y Lan, Z Dai, W Chen, W Cai, JA Kovacs, L Ma, X Tang
Journal of clinical microbiology, 2014•Am Soc MicrobiolWe investigated Pneumocystis jirovecii dihydropteroate synthase (DHPS) and dihydrofolate
reductase (DHFR) genes for mutations in 25 Chinese HIV-infected patients with P. jirovecii
pneumonia. We identified DHPS mutations in 3 (12%) patients and DHFR mutations in 1
(4%) patient. The prevalence of DHPS and DHFR mutations in China remains low, as it does
in other developing countries.
reductase (DHFR) genes for mutations in 25 Chinese HIV-infected patients with P. jirovecii
pneumonia. We identified DHPS mutations in 3 (12%) patients and DHFR mutations in 1
(4%) patient. The prevalence of DHPS and DHFR mutations in China remains low, as it does
in other developing countries.
Abstract
We investigated Pneumocystis jirovecii dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) genes for mutations in 25 Chinese HIV-infected patients with P. jirovecii pneumonia. We identified DHPS mutations in 3 (12%) patients and DHFR mutations in 1 (4%) patient. The prevalence of DHPS and DHFR mutations in China remains low, as it does in other developing countries.
American Society for Microbiology