Background Migraine is a prevalent and debilitating disease that may, in part, arise because
of disruption in neurovascular endothelia caused by elevated homocysteine. This study
examined the homocysteine-lowering effects of vitamin supplementation on migraine
disability, frequency and severity and whether MTHFRC677T genotype influenced treatment
response. Methods This was a randomized, double-blind placebo, controlled trial of 6
months of daily vitamin supplementation (ie 2 mg of folic acid, 25 mg vitamin B 6, and 400 μg …