Professor of MJedicin: 3, University of Toronto pERNICIOUS anemia, the subject selected by your Council for my address, is one of great interest and importance both to the profession a. nd to the public. Within recent years the public genera. lly has become familiar with the serious nature of this forn of anaemia, and nmany patients when told by their physicians they are suffering from anmemia anxiously enquire," Is it pernicious anemiae" The general practitioner is familiar with the discouraging results obtained from the many forms of treatment suggested for the disease, and the clinical investigator with its baffling nature. Although the outlook may be discouraging to patient and physician alike it is not without hope. Much can be done by early diagnosis and careful treatment to prolong the lives of those suffering from the disease. In my address to you to-day, it is impossible to refer to all phases of the problem, andI shall confine my remarks chiefly to some points in the early diagnosis and treatmen. t of this disease.