Project MUSE®: Human Biology - Latest Articles
https://muse.jhu.edu/journal/79
Project MUSE®: Latest articles in Human Biology.daily12026-05-11T00:00:00-05:00text/htmlen-USVol. 73 (2001) through current issueLatest Articles: Human BiologyTWOProject MUSE®Human Biology1534-66170018-7143Latest articles in Human Biology. Feed provided by Project MUSE®A Square Peg in a Round Hole: The Isolated Chitrali Population Displays the Lowest Consanguinity Rate in Pakistan
https://muse.jhu.edu/article/973712
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The population of Pakistan is widely recognized for its high levels of inbreeding, with consanguinity rates ranging from 55% to 65%—significantly higher than those reported in other South Asian countries such as India (7.3%) and Bangladesh (6%–17%) and even many Arab nations, including Jordan (27.5%) and Saudi Arabia (61%) (Anwar et al. 2020; Bittles 2001; Bittles and Black 2015; El Goundali et al. 2022; Islam 2021; Kumari et al. 2020; Yousef et al. 2024). Among consanguineous unions, first-cousin marriages—particularly those between paternal and maternal cousins—are the most prevalent (Nawaz et al. 2021; Tufail et al. 2017).Although recent trends in some regions suggest a modest decline in consanguinity
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Project MUSE®https://muse.jhu.edu/2026-05-11T00:00:00-05:00https://muse.jhu.edu/journal/79/image/coversmallA Square Peg in a Round Hole: The Isolated Chitrali Population Displays the Lowest Consanguinity Rate in Pakistan2025-11-05text/htmlen-USA Square Peg in a Round Hole: The Isolated Chitrali Population Displays the Lowest Consanguinity Rate in Pakistan2025-11-052025TWOProject MUSE®870202026-05-11T00:00:00-05:002025-11-05APOE Genotype Distribution in a Mexican Population: A Comparative Study and Its Implications for Alzheimer's and Cardiovascular Disease
https://muse.jhu.edu/article/973713
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The apolipoprotein E (APOE) gene, located on chromosome 19q13.32, encodes ApoE, a protein involved in lipid metabolism that plays a crucial role in cholesterol transport, neuronal repair, and synaptic plasticity (Aceves et al. 2006; Mahley and Rall 2000). The APOE gene has three major allelic variants—ε2, ε3, and ε4—which are determined by two key single nucleotide polymorphisms (SNPs): rs429358 and rs7412. These SNPs can present different nucleotide variants, and their specific combination on the same chromosome defines the haplotype. The rs429358 variant determines whether the amino acid position 130 encodes arginine (C allele) or cysteine (T allele), while the rs7412 variant determines whether position 176
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Project MUSE®https://muse.jhu.edu/2026-05-11T00:00:00-05:00https://muse.jhu.edu/journal/79/image/coversmallAPOE Genotype Distribution in a Mexican Population: A Comparative Study and Its Implications for Alzheimer's and Cardiovascular Disease2025-11-05text/htmlen-USAPOE Genotype Distribution in a Mexican Population: A Comparative Study and Its Implications for Alzheimer's and Cardiovascular Disease2025-11-052025TWOProject MUSE®734822026-05-11T00:00:00-05:002025-11-05Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among Indian Populations: A Systematic Review
https://muse.jhu.edu/article/973714
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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most prevalent enzyme deficiencies in the world (Nkhoma et al. 2009). The global prevalence of G6PD deficiency is geographically correlated with areas inhabited by populations historically exposed to endemic malaria, including Africa, Mediterranean Europe, Southeast Asia, and Latin America. In the United States, for example, enzyme deficiency primarily affects populations of African and Mediterranean descent (Wajcman and Galactéros 2004). This high correlation of G6PD deficiency with geographic areas where malaria is endemic has led scientists to hypothesize that perhaps G6PD deficiency deliberately protects against malaria (Tripathy and Reddy 2007).
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Project MUSE®https://muse.jhu.edu/2026-05-11T00:00:00-05:00https://muse.jhu.edu/journal/79/image/coversmallPrevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among Indian Populations: A Systematic Review2025-11-05text/htmlen-USPrevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among Indian Populations: A Systematic Review2025-11-052025TWOProject MUSE®993262026-05-11T00:00:00-05:002025-11-05Chimerism in Males and Recurrent Miscarriages: A Case Study
https://muse.jhu.edu/article/973715
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Most humans have a single genetic code. When humans are conceived, the parents' chromosomes combine to form a unique genome, which persists for life. However, under certain conditions, one body can contain two distinct genomes, in contrast to a mosaic, where different cell lines originate from a single zygote (Anderson et al. 1951). In 1953, the first confirmed human chimera, a woman known as Mrs. McK, discovered she had two blood types, A and O, after donating blood (Dunsford et al. 1953). Human chimeras have been recognized for nearly 70 years by clinicians and cytogeneticists. However, public interest surged in the past two decades due to three high-profile media cases related to parentage testing: Karen, who
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Project MUSE®https://muse.jhu.edu/2026-05-11T00:00:00-05:00https://muse.jhu.edu/journal/79/image/coversmallChimerism in Males and Recurrent Miscarriages: A Case Study2025-11-05text/htmlen-USChimerism in Males and Recurrent Miscarriages: A Case Study2025-11-052025TWOProject MUSE®440542026-05-11T00:00:00-05:002025-11-052021 Gabriel W. Lasker Award
https://muse.jhu.edu/article/973716
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Gabriel W. Lasker served as editor of Human Biology from 1953 to 1988 (Mascie-Taylor 2002). Each year, Human Biology recognizes the most significant contribution to the journal with an award named in his honor. The 2021 Gabriel W. Lasker Award is presented to Briana T. New, Bridget F. B. Algee-Hewitt, M. Katherine Spradley, Lars Fehren-Schmitz, Cris E. Hughes, Bruce E. Anderson, Marek E. Jasinski, Joanna Arciszewska, Grażyna Zielińska, Maria Szargut, Sandra Cytacka, and Andrzej Ossowski for their paper "Comparing Genetic Variation among Latin American Immigrants: Implications for Forensic Casework in the Arizona- and Texas-Mexico Borderlands" (New et al
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Project MUSE®https://muse.jhu.edu/2026-05-11T00:00:00-05:00https://muse.jhu.edu/journal/79/image/coversmall2021 Gabriel W. Lasker Award2025-11-05text/htmlen-US2021 Gabriel W. Lasker Award2025-11-052025TWOProject MUSE®34022026-05-11T00:00:00-05:002025-11-05