The Quest for Cortisone

Title Page, Copyright

T h e Q u e s T f o r C o rT i s o n e Thom rooke Michigan state university Press east Lansing Copyright © 2012 by Mayo Foundation for Medical Education and Research i The paper used in this publication meets the minimum requirements of ANSI/NISO Z39.48-1992 (R 1997) (Permanence of Paper). Michigan State University Press East Lansing, Michigan 48823-5245 Printed and bound in the United States of America. 18 17 16 15 14 13 12 1 2 3 4 5 6 7 8 9 10 library of congress cataloging-in-publication data Rooke, Thom W. The quest for cortisone / Thom Rooke. p. cm. Includes bibliographical references. ISBN 978-1-61186-033-7 (pbk. : alk. paper) I. Title. 1. Kendall, Edward C. (Edward Calvin), 1886-1972. 2. Hench, Philip S. (Philip Showalter), 1896-1965. 3. Mayo Clinic. 4. Cortisone—history—United States. 5. Clinical Trials as Topic—history—United States. 6. Cortisone—therapeutic use—United States. 7. Drug Discovery—history—United States. 8. Drug Evaluation—history—United States. 9. History, 20th Century—United States. 610.72'4—dc23 2011031277 Book design by Scribe Inc (www.scribenet.com) Cover design by David Drummond, Salamander Design, Inc. Cover photo of Edward C. Kendall, PhD, and Philip S. Hench, MD, in Dr. Kendall’s laboratory, taken November 15, 1949, after the announcement of their receipt of the 1950 Nobel Prize in Physiology or Medicine for the discovery of cortisone. Used with permission of Mayo Foundation for Medical Education and Research. All rights reserved. G Michigan State University Press is a member of the Green Press Initiative and is committed to developing and encouraging ecologically responsible publishing practices. For more information about the Green Press Initiative and the use of recycled paper in book publishing, please visit www.greenpressinitiative.org. Visit Michigan State University Press at www.msupress.org This book is dedicated to P. J. O’Rourke . . . my literary idol and inspiration. Someday I hope you’ll let me buy the first round. I would like to thank my wife, Julie, for her hard work and editing expertise. This is a better book because of her. ...