This handbook presents the science and practice of eHealth evaluation based on empirical evidence gathered over many years within the health informatics discipline. The handbook describes different approaches used to evaluate the planning, design, implementation, use and impact of eHealth systems in different health settings. It also provides a snapshot of the current state of knowledge on the consequences of opting for eHealth systems with respect to their effects and implications on provider performance and health outcomes. This book is licensed under a Creative Commons Attribution-NonCommercial 4.0 license (CC BY-NC). Third party copyrighted material has been used with permission. Any further reuse must be cleared directly with the rights holder.