In this Book

buy this book Buy This Book in Print
summary
We expect medicine to progress in an orderly fashion, with good medical practices being replaced by better ones. But some tests and therapies are discontinued because they are found to be worse, or at least no better, than what they replaced. Medications like Vioxx and procedures such as vertebroplasty for back pain caused by compression fractures are among the medical “advances” that turned out to be dangerous or useless. What Dr. Vinayak K. Prasad and Dr. Adam S. Cifu call medical reversal happens when doctors start using a medication, procedure, or diagnostic tool without a robust evidence base—and then stop using it when it is found not to help, or even to harm, patients. Drs. Prasad and Cifu narrate fascinating stories from every corner of medicine to explore why medical reversals occur, how they are harmful, and what can be done to avoid them. They explore the difference between medical innovations that improve care and those that only appear to be promising. They also outline a comprehensive plan to reform medical education, research funding and protocols, and the process for approving new drugs that will ensure that more of what gets done in doctors’ offices and hospitals is truly effective.

Table of Contents

  1. Cover
  2. restricted access
    • Download PDF Download
  1. Title Page, Copyright, Dedication
  2. pp. i-vi
  3. restricted access
    • Download PDF Download
  1. Contents
  2. pp. vii-x
  3. restricted access
    • Download PDF Download
  1. Introduction
  2. pp. 1-8
  3. restricted access
    • Download PDF Download
  1. Part I. Medical Reversal: Examples, Frequency, and Consequences
  1. 1. What Is Medical Reversal?
  2. pp. 11-19
  3. restricted access
    • Download PDF Download
  1. 2. Subjective Outcome: Why Feeling Better Is Often Misleading
  2. pp. 20-29
  3. restricted access
    • Download PDF Download
  1. 3. Surrogate Outcomes
  2. pp. 30-42
  3. restricted access
    • Download PDF Download
  1. 4. Screening Tests
  2. pp. 43-56
  3. restricted access
    • Download PDF Download
  1. 5. Systes Failure
  2. pp. 57-68
  3. restricted access
    • Download PDF Download
  1. 6. Finding Flawed Therapies on Our Own
  2. pp. 69-80
  3. restricted access
    • Download PDF Download
  1. 7. The Frequency of Medical Reversal
  2. pp. 81-87
  3. restricted access
    • Download PDF Download
  1. 8. The Harms of Medical Reversal: Today’s Patients, Tomorrow’s Patients, and the Health-Care Field
  2. pp. 88-96
  3. restricted access
    • Download PDF Download
  1. Part II: An Interlude on Evidence
  1. 9. A Primer on Evidence-Based Medicine: What Is Evidence in Medicine?
  2. pp. 99-108
  3. restricted access
    • Download PDF Download
  1. 10. What Really Made You Better: When Evidence Gets Complicated
  2. pp. 109-122
  3. restricted access
    • Download PDF Download
  1. Part III: The Origins of Reversal
  1. 11. Scientific Progress, Revolution, and Medical Reversal
  2. pp. 125-134
  3. restricted access
    • Download PDF Download
  1. 12. Sources of Flawed Data
  2. pp. 135-147
  3. restricted access
    • Download PDF Download
  1. 13. Why Are We so Attracted to Flawed Therapies?
  2. pp. 148-158
  3. restricted access
    • Download PDF Download
  1. Part IV: Beyond Reversal
  1. 14. Medical Education: A Very Good Place to Start
  2. pp. 161-172
  3. restricted access
    • Download PDF Download
  1. 15. Academic Medicine
  2. pp. 173-182
  3. restricted access
    • Download PDF Download
  1. 16. Reforming the System: The Burden of Proof and Nudging Our Way Past Reversal
  2. pp. 183-194
  3. restricted access
    • Download PDF Download
  1. 17. How Not to Become a Victim of Reversal
  2. pp. 195-204
  3. restricted access
    • Download PDF Download
  1. 18. Beyond Dogma: When Randomized Trials Are Unnecessary
  2. pp. 205-214
  3. restricted access
    • Download PDF Download
  1. Acknowledgments
  2. pp. 215-216
  3. restricted access
    • Download PDF Download
  1. Appendix
  2. pp. 217-246
  3. restricted access
    • Download PDF Download
  1. References
  2. pp. 247-256
  3. restricted access
    • Download PDF Download
  1. Index
  2. pp. 257-265
  3. restricted access
    • Download PDF Download

Additional Information

ISBN
9781421417738
Related ISBN
9781421417721
MARC Record
OCLC
966392007
Pages
280
Launched on MUSE
2016-12-18
Language
English
Open Access
No
Back To Top

This website uses cookies to ensure you get the best experience on our website. Without cookies your experience may not be seamless.