This study demonstrates ways that geopolitics may interfere with the pursuit of global science. In particular, the study sought to understand the impact of the U.S. Department of Justice's China Initiative on the U.S. scientific community, especially among those of Chinese and other Asian descent. Based on a survey of about 2,000 scientists in top U.S. research universities, findings show a consistent pattern of neo-racism, neo-nationalism, and the consequences for future international collaborations and maintaining highly skilled talent. The findings show how neo-racism and neo-nationalism may be sabotaging the efforts of the U.S. to be globally competitive.