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This qualitative study aimed to understand sociocultural influences on sexual decision-making among nineteen African American college women at a Historically Black College. Results show that family, particularly matriarchs or mothers, have a major influence on sexual decision-making. The college campus was an important resource for sexual health information and HIV/STI testing. Fear of negative consequences related to religion was the primary reason for abstinence. Protective behaviors among sexually active participants included condom and contraceptive use, and HIV/STI testing. Findings indicate that parent-child communication about sex is critical, and that sexual health information, contraceptives, and STI/HIV testing should be available on campus.