The Ottoman Empire's vast territory held more than one thousand cities with a population ranging from around 100 to more than 100,000 households. This essay aims to sketch out a typology of these Ottoman cities in terms of their three basic socio-spatial features to allow them to be studied from a comparative perspective vis-à-vis other Ottoman and world cities. Thus, the key research themes of this article are the similarities and differences, groupings and idiosyncrasies, and common trends and singularities of Ottoman cities. It uses a relational approach to define and map Ottoman cities synchronically, and in some cases diachronically, according to their different attributes in different geographies and time periods. It focuses on forty-five cities selected from the Balkan, Anatolian, and Arab regions of the empire during the period 1450–1700 on the basis of the research literature and archival sources, including taḥrīr (cadastral) surveys and ʿavāriż (extraordinary tax) surveys. This essay's conclusions are based on a project that scanned scholarly publications and primary sources, selected a representative number of the cities, gathered data about these cities, set up a database, explored the attributes-based typologies of the cities, and presented the outcomes by means of tables and maps using SPSS and GIS.