To ensure its survival, Adlerian therapy must achieve recognition as an evidence-based approach in the very near future. This treatment manual is intended to guide the clinical trials that are a necessary prerequisite for becoming evidence based. This manual describes the standardized therapeutic approach that is the basis of these clinical trials with individuals meeting criteria for clinical depression. It describes the origins of this approach in Adlerian therapy as well as the assumptions, components, and therapeutic elements of Adlerian pattern-focused therapy. It also defines this standardized approach in terms of its overall structure, including its duration, format, number and length of sessions, and session format, as well as guidelines for its actual practice. A case example illustrates this approach.