During a two-year period, from 2009 to 2010, a multidisciplinary team conducted multispectral imaging, digital processing and data management of the Syriac Galen Palimpsest. This contractor-led team applied the turnkey multispectral imaging techniques developed in earlier advanced imaging projects to this palimpsest. This required new management techniques and work processes to provide useful results efficiently and quickly, while minimizing risk. In the initial risk-mitigation study phase, the team first imaged several leaves of the bound SGP in 2009 to characterize the imaging and processing challenges. Building on the findings from this first phase, they then imaged all the disbound leaves in 2010. Management of the SGP imaging and processing focused on integration of the people, processes and technology into an efficient imaging system. This included planning and managing the data flow, data replication, image processing and production of the image product while avoiding bottlenecks. With over 300 GB of data hosted for open access, this project provided opportunity for further study and collaboration, and multispectral imaging work processes used on subsequent programs. This access to the online images allowed a global team of scholars to conduct independent research, during which they also discovered leaves missing from the bound manuscript.