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Meeting the needs of current and future transgender individuals is a pressing medical concern. The transgender community faces unique health issues, including an elevated risk of HIV infection in male-to-female transgender people and high rates of violence, suicide, and substance abuse. Unfortunately, many trans people avoid seeking treatment because they have experienced discrimination, hostility, and refusal of medical care because of their status. Health-care workers who are not transphobic simply may not understand enough about the medical process of transitioning to adequately care for these patients. Hospitalists—specialists in inpatient medicine—are uniquely positioned to change this trajectory. We believe that as this burgeoning cohort of doctors takes on an expanded role in medicine, they should take the lead in the care of hospitalized transgender patients and in providing education to trainees about medical issues pertinent to this group of underserved and marginalized patients.