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Called “America’s Lourdes,” the Shrine of Our Lady of Consolation in Carey, Ohio, has been the site of dozens of reported physical healings. Beginning in 1875 and peaking in the first decades of the twentieth century, the reports of healings brought thousands of pilgrims to the shrine, many of them seeking cures. This study observes the development of the shrine at a time of significant medical advances and argues that any attempt to understand the cures reported to have taken place there must be viewed against the backdrop of scientific progress. While the reported healings may have appeared to challenge science by reasserting illness as mysterious and divinely-sanctioned, the pilgrims and those who promoted the cures were not often antagonists to medical progress but believed they served as witnesses to the role of religious faith in healing what medicine could not cure.