This paper presents findings of a Mellon Foundation–funded study conducted at Penn State University in University Park during Fall 2012 that explored scholars’ information practices across disciplines encompassing the sciences, humanities, and social sciences. Drawing on results of the Web-based survey and ethnographic interviews, we present findings related to academics’ practices in discovering, storing, citing, and archiving information, as well as their views on the role of library in the digital age. The paper harvests a comparative multidisciplinary perspective of our study, identifying principles and technical architecture that support digital scholarship and facilitate the development of literacies for faculty personal information management.