This special issue of Biography may seem exotic. It engages with a series of concepts that are unusual in studies of life narrative: beginning with zoegraphy and ending with the anthropocene. It turns to scenes of auto/biographical expression that may seem bizarre: animalographies, bioart, narratives of chronic pain, autobiogeography. It embraces creatures, critters, produsers, and avatars. Its critical canon is not traditionally associated with studies of life narrative: Bruno Latour, Deleuze and Guattari, Cary Wolfe, Donna Haraway, Rosi Braidotti, Jane Bennett, Neil Badmington, Judith Butler, Giorgio Agamben. The critical issues, concepts, and contexts we engage with in this issue, however, are anything but exotic. To the contrary: what it means to be human is a question that is fundamental to autobiographical narrative, and embedded in the history of autobiography in western modernity. Around posthumanism an assemblage of work is emerging that is important for critical work on life narrative now, and the essays in this special issue suggest why this is so.