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This study evaluates the factors associated with utilization of generic drug discount program (GDDP) among federally qualified health center (FQHC) patients in Houston, Texas. A survey to determine awareness and use of GDDP was administered to 304 patients at three FQHCs in Houston, Texas. Patients at FQHCs treated with courtesy by pharmacy staff (OR: 14.1, 95% CI: 7.9-25.2), patients with a perception of positive impact of GDDP on their health (OR: 7.6, 95% CI: 4.5-12.7), those who found GDDP easy to use (OR: 6.6, 95% CI: 3.8-11.6), were more likely to utilize GDDP. Approximately 56% of the participants had utilized the GDDP at least once in the past 12 months. Approximately 85% of participants indicated that they would use GDDP if recommended by a physician. It is possible for FQHCs to be good venues for increasing awareness and utilization of GDDP.