In this article I explore the powerful sense of regional solidarity that accompanied the rise of Silicon Valley. From the early years of Stanford University, the university's leaders saw its mission as service to the West and shaped the school accordingly. At the same time, the perceived exploitation of the West at the hands of eastern interests fueled booster-like attempts to build self-sufficient indigenous local industry. Thus, regionalism helped align Stanford's interests with those of the area's high-tech firms for the first fifty years of Silicon Valley's development. The distinctive regional ethos of the West during the first half of the twentieth century is an ingredient of Silicon Valley's already prepared environment, an ingredient that would-be replicators ignore at their peril.