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  • Bacterial Genetics, Antibiotic Usage, and Public Policy:The Crucial Interplay in Emerging Resistance
  • Thomas Fekete
Thomas Fekete
Section of Infectious Diseases, Temple University Health Sciences Center, 3401 North Broad Street, Philadelphia, Pennsylvania 19140


1. NASH, J. M. Attack of the superbugs. Time 140:62-63, 1992.
2. SCHMIDT, K. F. The troubling ghosts of scourges past. U.S. News & World Report 113:70-71, 1992.
3. MARTIN, J. E.; LESTER, A.; and PRICE, E. V. Comparative study of gonococcal susceptibility to penicillin in the United Staes. J. Infect. Dis. 122:459-461, 1970.
4. OLSEN, G. A. Consumption of antibiotics in Greenland, 1964-1970. IV: Changes in the sensitivity of Neisseria gonorrhoeae to antibiotics. Br. J. Vener. Dis. 49:33-41, 1973.
5. KAM, K. M,; LAI, C. F.; EGGLESTONE, S.; and CHAN, C. B. Patterns of antibiotic susceptibility of gonococci isolated in Hong Kong, 1987-1990. Sex. Transmitt. Dis. 19:284-287, 1992.
6. COHEN, S. P.; YAN, W.; and LEVY, S. B. A multidrug resistance regulatory chromosomal locus is widespread among enteric bacteria. J. Infect. Dis. 168: 484-488, 1993.
7. O'BRIEN, T. F.; ACAR, J. F.; MEDEIROS, A. A.; et al. International comparison of prevalence of resistance to antibiotics. JAMA 239:1518-1523, 1978.
8. HUGHES, V. M., and DATTA, N. Conjugative plasmids in bacteria of the "pre-antibiotic" era. Nature 302:725-726, 1983.
9. MURRAY, B. E.; RENSIMER, E. R.; and DUPONT, H. L. Emergence of highlevel trimethoprim resistance in fecal Escherichia coli during oral administration of trimethoprim or trimethoprim-sulfamethoxazole. New Eng. J. Med. 306:130-135, 1982.
10. BRUNTON, J.; CLARE, D.; and MEIER, M. A. Molecular epidemiology of antibiotic resistance plasmids in Haemophilus species and Neisseria gonorrhoeae. Rev. Infect. Dis. 8:713-724, 1986.
11. BRUMFITT, W., and HAMILTON-MILLER, J. Methicillin-resistant Staphylococcus aureus. New Eng. J. Med. 320:1188-1196, 1989.
12. WESTH, H.; JARLOV, J. O.; KJERSEM, H.; and ROSDAHL, V. T. The disappearance of multiresistant Staphylococcus aureus in Denmark: Changes in strains of the 83 A complex between 1969 and 1989. Clin. Infect. Dis. 14:1186-1194, 1992.
13. HOLMBERG, S. D.; OSTERHOLM, M. T.; SENGER, K. A.; and COHEN, M. L. Drug-resistant salmonella from animals fed antimicrobials. New Eng. J. Med. 311:617-622, 1984.
14. HINSHAW, J. C., and FELDMAN, W. H. Streptomycin in treatment of clinical tuberculosis: A preliminary report. Proc. Staff Meet Mayo Clin. 20:313-318, 1945.
15. CORONADO, V. G.; BECK-SAGUE, C. M.; HUTTON, M. D.; et al. Transmission of multidrug-resistant Mycobacterium tuberculosis among persons with human immunodeficiency virus infection in an urban hospital: Epidemiologic and restriction fragment length polymorphism analysis. J. Infect. Dis. 168:1052-1055, 1993.
16. SMALL, P. M.; HOPEWELL, P. C.; SINGH, S. P.; et al. The epidemiology of tuberculosis in San Francisco. New Eng. J. Med. 330:1703-1709, 1994.
17. FLEMING, A. On the antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of H. influenzae. Br. J. Exp. Pathol. 10:226-236, 1929.
18. KIRBY, R. Evolutionary origin of the class A and class C β-lactamases. Mol. Evolution 34:345-350, 1992.
19. KELLY, J. A.; DIDERBERG, O.; CHARLIER, P.; et al On the origin of bacterial resistance to penicillin: Comparison of a β-lactamase and a penicillin target. Science 231:1429-1431, 1986.
20. MEDEIROS, A. A. β-lactamases. Br. Med. Bull. 40:18-27, 1984.
21. SUTCLIFFE, J. G. Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc. Nat. Acad. Sci. 75:3737-3741, 1978.
22. SANDERS, C. C., and SANDERS, W...


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