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The major concept of epistemology—or epistemologies—is discussed, as well as related terms such as paradigm and science. Also covered are two broad paradigms, the clinical and the cultural, that seem to drive theorizing, research, and practice regarding individuals who are d/Deaf or hard of hearing. The two paradigms emanate from different epistemologies and might account for much of the tension in research and practice. Finally, the authors present their view on the nature of scholarly inquiries—namely, that theory, research, and practice should adhere to the principles of a multiparadigmatic science.