In the present study, fourteen science and engineering faculty members who identified as lesbian or gay at two research universities described the workplace climate for lesbian, gay, bisexual, and transgender (LGBT) faculty, the role pressures and choices they face, and the effects of the climate on their work performance and careers. While some faculty describe overt hostility toward them, invisibility, interpersonal discomfort, and pressure to "cover" their sexuality are much more pervasive, as is a felt obligation to be supportive to LGBT students and junior colleagues. Based on our analyses of the interview data, we propose a model of the career consequences of the academic work environment for sexual minority faculty in science and engineering. We conclude by recommending specific future research and suggesting institutional actions that can be taken to make campus climates more affirming for LGBT faculty in science and engineering, and other disciplines.