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Intended both as an introduction to the thought of the Italian philosopher Roberto Esposito and as a mapping of current biopolitical practice, this essay traces the contributions and the limits of recent Italian contributions to the discussion of biopolitics. The essay offers a summary of Esposito's insight into the relation of community and immunity and compares his thinking to other philosophers who take immunity as their object of study (particularly Jacques Derrida). Campbell goes on to read Esposito's privileging of bios in the light of Giorgio Agamben's emphasis on zōē, while making reference as well to Antonio Negri and Michael Hardt's understanding of biopower. He concludes by arguing that the stakes of Esposito's analysis for an affirmative biopolitics concern fundamentally the nature of community and its opening to all life forms as bios.