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Systematic reviews are review articles that are completed using predefined methods to minimize bias inherent to observational studies. Systematic reviews are important to librarians because they integrate evidence across studies or data resources to provide knowledge that is useful to good decision making in our profession. In addition, as more systematic reviews are being published in many disciplines, librarians are being asked to assist with the production of them—-comprehensive searching is vital to the strength of the reviews. This article describes the process of producing systematic reviews and also describes their use. Librarians can acquire the skills necessary to use and produce high-quality systematic reviews.