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Haptoglobin Gene Promoter Polymorphism and Haplotypes Are Unique in Different Populations
- Human Biology
- Wayne State University Press
- Volume 78, Number 1, February 2006
- pp. 121-126
- 10.1353/hub.2006.0029
- Article
- Additional Information
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Abstract We investigated the distribution of haptoglobin (HP) alleles and haplotypes among Africans (Ghanaians), Europeans (from South Africa), and Chinese. HP*1F was present only in Africans and Europeans, whereas HP*del was unique to Chinese. Six base substitutions at the promoter region were population specific. Only 3 out of 18 haplotypes were shared among the populations. A probable application of HP in human population genetics appears legitimate.