Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial
RF Anton, SS O'Malley, DA Ciraulo, RA Cisler… - Jama, 2006 - jamanetwork.com
ContextAlcohol dependence treatment may include medications, behavioral therapies, or
both. It is unknown how combining these treatments may impact their effectiveness,
especially in the context of primary care and other nonspecialty settings. ObjectivesTo
evaluate the efficacy of medication, behavioral therapies, and their combinations for
treatment of alcohol dependence and to evaluate placebo effect on overall outcome. Design,
Setting, and ParticipantsRandomized controlled trial conducted January 2001-January 2004 …
both. It is unknown how combining these treatments may impact their effectiveness,
especially in the context of primary care and other nonspecialty settings. ObjectivesTo
evaluate the efficacy of medication, behavioral therapies, and their combinations for
treatment of alcohol dependence and to evaluate placebo effect on overall outcome. Design,
Setting, and ParticipantsRandomized controlled trial conducted January 2001-January 2004 …