Raman optical activity (ROA) measures vibrational optical activity by means of a small
difference in the intensity of Raman scattering from chiral molecules in right and left
circularly polarized incident laser light. The ROA spectra of a wide range of biomolecules in
aqueous solution can now be measured routinely. Because of its sensitivity to the chiral
elements of biomolecular structure, ROA provides new information about solution structure
and dynamics complementary to that supplied by conventional spectroscopic techniques …

Abstract Background and Objectives Patient function has been conceptualized by clinical
measures such as joint motion, muscle strength, disability, and general health status. The
purpose of the current study was to evaluate tumor and treatment variables predictive of
these conceptually different posttreatment functional outcomes in patients treated with limb
preservation surgery for lower‐extremity soft tissue sarcoma. Methods One hundred seventy‐
two patients with minimum 1‐year follow‐up were evaluated using the following outcomes …

OBJECTIVE To investigate whether an oral loading dose of flecainide is as safe and
effective as intravenous flecainide for the cardioversion of acute atrial fibrillation. DESIGN
Prospective, randomised, double blind, double placebo study. SETTING Cardiac care unit of
a large district general hospital in the UK. PATIENTS AND METHODS 79 patients presenting
with symptomatic acute atrial fibrillation: patients were given either intravenous flecainide
(n= 39) or a solution of oral flecainide (n= 40), with appropriate placebos. All patients were …