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approaches have been given adequate opportunity to describe their techniques. Sonication, salt extraction, enzymatic methods, and the use of detergents are discussed and compared. Methods for characterizing the biological properties of native and solubilized antigen are discussed in the several chapters. Techniques for evaluating immunogenicity, for measuring effects on mixed leukocyte reactivity, graft survival, and delayed-type hypersensitivity, and for following the reactivity of antigen with antibody are described. The final section, "Horizons in Antigen Research," includes chapters by the editors on "Perspectives on the Role of HL-A Antigens and the Molecular Nature of HL-A Antigens." The final chapter, by G. J. V. Nossal, is entitled "Prospectus: Future Adventures in Transplantation Antigen Research." This book is a compendium ofuseful recent information. It provides considerable detail without being ponderous. Although written by several authors, it is quite readable. Frank Fitch Department of Pathology University of Chicago Exploring New Ethicsfor Survival: The Voyage ofthe Spaceship "Beagle." By Garrett Hardin. Baltimore: Penguin Books, 1973. Pp. 273. $1.45. Professor Garrett Hardin has done some of the most provocative lecturing and writing on the relationship between population and the limited resources of the earth. This book may be his best to date. His examination of the threats to man's future and possible alternatives to disaster is witty and scary. He combines examination of the problems of ecology with a science fiction tale of the voyage of an enormous spaceship in search of another inhabitable planet. Human foibles come to dominate life in this planned society as they have on the spaceship Earth. Hardin's ideas deserve to be a part of the debate on man's sins against nature and the future, whether or not the reader agrees with all that he says. DwightJ. Ingle University of Chicago Who Should Have Children? An Environmental and Genetic Approach. By DwightJ. Ingle. Indianapolis: Bobbs-Merrill Co., 1973. Pp. 141. $6.95 (cloth); $1.95 (paper). Dr. Dwight J. Ingle is professor (now emeritus) of physiology at the University of Chicago, a position to which he came with a fine background of research in basic science and of practical work in the pharmaceutical industry. Few practicing physicians nowadays take time to think about problems apart from their practice. Few investigators in the basic sciences take time to think, but Dwight Ingle is a thinker. He thinks clearly and all the time objectively and scientifically. This extraordinary habit has involved him in many controversies, particularly with so290 J Book Reviews ...

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