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Segregation Analysis of Blood Pressure and Body Mass Index in a Rural US Community
- Human Biology
- Wayne State University Press
- Volume 74, Number 1, February 2002
- pp. 11-23
- 10.1353/hub.2002.0010
- Article
- Additional Information
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To assess evidence for a gene with large effect on systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI), we conducted segregation analyses on 261 nuclear families collected from a rural Caucasian community in Michigan. The families were ascertained through a hypertensive proband. Each phenotype was adjusted for significant covariate effects (e.g., gender and age). We used class D regressive models to conduct the segregation analyses. Our analysis results support the segregation of a major gene for BMI, but not for SBP or DBP. A recessive locus effect provided the best explanation for BMI where ~>43% of the variance of BMI was due to this gene.