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  Volume 47, Number 4, Autumn 2004

Table of Contents

From: Perspectives in Biology and Medicine

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Special Issue: Clinical Research: Twenty-Five years of Increasing Concern for the Linchpin of Medical Advances

Clinical Research: twenty-five years of increasing concern for the linchpin of medical advances

p. 475
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Editors' Introduction: Why is Revitalizing Clinical Research So Important, Yet So Difficult?

pp. 476-486
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Historical Perspectives

Remembering the "Golden Years" of Patient-Oriented Clinical Research: a collective conversation

pp. 487-504
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Denny-Brown, Boston City Hospital, and the History of American Neurology

pp. 505-518
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Children in Medical Research: balancing protection and access: has the pendulum swung too far?

pp. 519-536
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The Formation of the American Society of Clinical Oncology and the Development of a Medical Specialty, 1964-1973

pp. 537-551
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Case Studies

Pathways of Innovation: a history of the first effective treatment for sickle cell anemia

pp. 552-563
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The UGDP Controversy: thirty-four years of contentious ambiguity laid to rest

pp. 564-574
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The Role of Anemia in Congestive Heart Failure and Chronic Kidney Insufficiency: the cardio renal anemia syndrome

pp. 575-589
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From the Great Barrier Reef to a "Cure" for the Flu: tall tales, but true

pp. 590-596
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Policy Issues

The Fundamentals of Clinical Discovery

pp. 597-607
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Essay Reviews

How Real is Fetal Alcohol Syndrome?

pp. 608-616
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The Male Pill: a biography of a technology in the making (review)

pp. 617-623
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Book Review

Darwin and the Barnacle: The Story of One Tiny Creature and History's Most Spectacular Scientific Breakthrough (review)

pp. 624-626
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Index

Volume 47 Index

pp. 627-632
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Research Areas

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