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INDEX Abrahamsen, Adele, 143–44 agency, 37, 58, 92, 173, 207 allele, 28, 34, 56, 109, 111, 184. See also gene aphids, 118, 207 Aristotle, 2, 14, 55, 223n17 artificiality, 45–46, 54, 222n9 bacteria, 46, 100–101, 138 Bazaga, Pilar, 48, 50–51, 103–4, 222n13 Bechtel, William, 131–32, 141–44, 153, 156–57, 234n16, 234n19, 236n32 Bernard, Claude, 12, 96–97, 230n18 Bhattacharya, Sudin, 160, 237n37 body plan, 37, 212, 243n9 Boniolo, Giovanni, 67–68, 210, 224n29 Borges, Jorge Luis, 17, 39, 166, 205 Caenorhabditis elegans, 34–35, 45–46, 100, 118, 120, 207, 223 canalization, 20–25, 38, 71, 98, 158, 218n6 cancer, 1, 26, 80, 104, 198 Calcott, Brett, 59–60, 62, 65–66 catastrophe theory, 72, 225n34 causal explanation, 8, 10, 15, 45, 52, 87, 97, 113, 134, 179, 198; and change-relatedness , 164; in classical epigenetics , 98; compared to mechanistic explanation, 91, 130–31, 204; and counterfactuals, 187; and difference-making, 118–19, 127, 159; interventionist account of, 91–96, 104–5, 110, 128; and manipulation, 101–2; and “mechanistic detail,” 107–8 (see also “causes without 302 ◂ INDEX mechanisms”); nonmechanistic, 109, 127, 130, 169, 186; and proximate -ultimate distinction, 60, 62, 66 causation, 8, 11, 45, 47, 61, 92, 117; conserved quantity theory of, 105; and counterfactuals, 93, 102, 105; downward, 106, 157; and epigenetics, 10, 102, 108, 124, 128; on higher levels of organization, 132; interlevel, 156; and invariance, 108–9, 127; mechanistic theory of, 10, 108, 122, 126, 166, 204; mental, 106; multifactorial, 22, 184; reciprocal , 57–58. See also proximate-ultimate distinction “causes without mechanisms,” 10, 127–28, 166, 178, 199, 204 cell differentiation, 18, 61, 78, 80, 86, 136, 143, 150, 154; (bi)stable, 160–66; changes in, 15, 162; field of, 26, 79, 159; processes, 68–69, 74; Waddington ’s epigenetic landscape model of, 71–72. See also reprogramming , cell cell division, 9, 24, 40 central dogma (of molecular biology), 30, 80, 82, 107, 136, 183, 220n20 chromatin, 34–35, 68, 130; marking, 25, 130; modification, 26, 32, 69, 80–81 cluster concept, 7, 88, 203. See also Wittgenstein complexity, 7, 9, 15, 18, 20, 31, 45, 69, 112, 122, 154, 162, 214; biological, 1, 9, 26, 36, 39, 91, 203, 206; Borges problem of, 17, 39, 166, 205; definition of, 15–16, 20; dynamic, 9, 15, 22, 39; epigenetic, 9–10, 19, 25, 27, 36–40, 67, 82, 166, 203–5, 208, 215; of genotype-phenotype relationship , 22, 81, 111, 117, 119; multilevel, 131; representation problem of, 16–17, 39, 166, 204; science, 202; structural, 9, 15, 22, 25, 39; Waddington on, 202 composition, 56, 144. See also decomposition constitutive explanation, 10, 61, 91, 134, 156, 159. See also mechanistic explanation counterfactual, 14, 52, 98, 102–3, 107, 191; account of causation, 93; explanation, 101; notion of invariance, 93, 104–5; population, 51, 53, 104; questions, 51, 53, 94, 97 (see also what-if-things-had-beendifferent -questions); situations, 46, 94, 175–78, 180, 187, 195–96 Craig, Lindsay, 43, 221n3 Craver, Carl, 136, 161; on interlevel relations, 156–59; on interventionist explanations, 107, 134, 155, 229n16; on the Hodgkin-Huxley model, 127; and machine metaphors , 142, 234nn17–18 Crick, Francis, 12, 30, 107, 130, 138, 146, 201 CRISPR, 154, 236n29 Cummins, Robert, 133, 142, 149 Darden, Lindley, 125, 142, 234nn17–18 Darwin, Charles, 30, 42, 186, 240n15 Davidson, Eric, 154, 226n40 ▸ 303 INDEX Davies, Paul W. C., 147, 150, 235nn22– 23 Dawkins, Richard, 18, 110; on Lamarck, 5; on replicator-vehicle concept, 31, 83; and selfish genes, 22, 207 decomposition 133, 143–44, 148, 150; functional, 235n22–23; and localization, 131, 146–47, 150, 153; structural, 235n22–23 Descartes, René, 137, 144 determination, 22, 32, 210 development, 24, 31, 54, 60, 65, 80, 110, 139–40, 155, 169, 173; causal analysis of, 3, 19, 202; changes during, 3, 26, 98, 118; complexity of, 19; of CRISPR, 154; embryonic, 18, 154, 160; environmental influence on, 4, 21, 25, 27, 33, 102, 111, 158, 190; epigenetic explanation of, 189, 193, 214; epigenetic regulation of, 26, 44, 115, 128, 150; of epigenetics, 23, 27, 85, 119, 174, 207, 209, 215; and evolution, 23, 58, 192, 199; of experiments , 186; and gene-regulatory networks, 154, 226n40; and genes, 19–20, 83, 85, 158, 172, 214; germ cell, 32; and heredity, 5, 8–10, 30, 39–40, 42, 55, 102, 107, 109, 115, 119, 126; human, 193; plastic, 4, 9, 149, 203; representation of with epigenetic landscape model, 69, 71...

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ISBN
9780822983408
Related ISBN
9780822945215
MARC Record
OCLC
1037272654
Pages
327
Launched on MUSE
2018-06-07
Language
English
Open Access
No
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