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132 Cold War Triangle Tony Holý with self-made canisters around 1970. His laboratory was very sparse and many reagents were homemade (Photo courtesy of Dana Holà archives). 133  ALBUM Tony Holý and his technicians in his laboratory around 1980. The tall lady in the background, Bela Novakova, taught him many skills and remained very devoted to him all along his career (Photo courtesy of Dana Holà archives). 134 Cold War Triangle Erik De Clercq, teaching biochemistry on the campus of KU Leuven in Kortrijk, around 1980 (Photo courtesy of Erik De Clercq archives). 135  ALBUM Symposium of a group of chemists in Kyoto around 1982. Nobel Prize laureate Gobind Khorana seated in second row, third from left. Last row: Richard (Dick) Walker (fifth from the right), Tony Holý (third from right) and Erik De Clercq (second from right) (Photo courtesy of Erik De Clercq archives). 136 Cold War Triangle Rudi Pauwels, who started the first AIDS laboratory at the Rega Institute in 1986. His system was copied in laboratories all over the world for more than twenty years. He was still a student at the pharmaceutical faculty at that time and obtained his Ph. D. in 1990 with the highest honors (Photo courtesy of Erik De Clercq archives). 137  ALBUM Two Japanese doctoral fellows at the Rega Institute: Masanori Baba on the left discovered antiviral activity in Piet Herdewijn’s compounds and was instrumental in other discoveries together with Rudi Pauwels. Takashi Sakuma, on the right, discovered the anti-VZV activity in the very first acyclic nucleoside phosphonates (Photo courtesy of Erik De Clercq archives). 138 Cold War Triangle In a Brussels restaurant around 1992. From left to right: John C. Martin, then Head of Research at Gilead Sciences, Etienne (Stevie) Davignon, Member of the Board of Directors of Gilead Sciences, Norbert Bischofberger, then Head of Development at Gilead Sciences, Michael Riordan, founder and first CEO of Gilead Sciences, and Erik De Clercq, Head of the Rega Foundation and Head of the Institute (Photo courtesy of Erik De Clercq archives). 139  ALBUM Photo taken at Gilead Sciences in 1992. From left to right: Erik De Clercq, John C. Martin, Tony Holý (Photo courtesy of Gilead Sciences). 140 Cold War Triangle Gilead Sciences maintained close contacts with the Rega Institute all through the 1990’s into the new Millennium. Here John C.Martin on one of his regular visits to Leuven around 1995. From left to right: Johan Neyts, then a postdoctoral fellow working on the potential of Cidofovir analogues to fight smallpox. Robert Snoeck was the clinician for most testings. He investigated the potential of cidofovir on viruses including the CMV virus. Lieve Naessens worked with Gilead Sciences on the development of the prodrug of Tenofovir. Jan Desmyter, then the head of clinical virology in the university hospital, was a vital supporter of the AIDS laboratories in the virology department of the Rega Institute. John C. Martin, then CEO of Gilead Sciences and Norbert Bischofberger, then the Head of Research at Gilead Sciences, Erik De Clercq then head of the Rega Foundation and head of the Institute, Graciela Andrei, who was instrumental in the discovery of the antiviral action of Cidovofir in papilloma viruses (Photo courtesy of Erik De Clercq archives). 141  ALBUM The launching of “Vistide” in 1996, the first commercial product of Gilead Sciences. The company had fewer than 200 employees at that time. Today Gilead is still a relatively small pharmaceutical company with 8,000 employees worldwide (Photo courtesy of Gilead Sciences). 142 Cold War Triangle Ninth International Conference on Antiviral Research (ICAR), May 21 1996, in Ura-bandai, Northern district of Fukoshima. First row (seating) from right to left: John C. Martin, Erik De Clercq, Mrs Chikako Shigeta, Shiro Shigeta, Earl Kern, Hugh Field, George Galasso, Rich Whitley. Towering above the whole scene: Raymond Schinazi and Naoki Yamamoto on third row far left (Photo courtesy of Erik De Clercq archives). 143  ALBUM From left to right: Tony Holý at a meeting in Atlanta in 1997, Mick Hitchcock who tested many compounds at Bristol-Myers and later at Gilead to determine which compounds to develop; Piet Herdewijn, presently Head of Medicinal Chemistry at the Rega Institute who synthesized d4T and many other nucleosides that are now part of Gilead Sciences’s library (Photo courtesy of Erik De Clercq archives). 144 Cold War Triangle Tenth International Conference on Antiviral Research (ICAR), April 1997, in Atlanta, Georgia. First row from left to right: George Galasso, Mrs. J. Galasso...


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