Index
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425 Index abdominal pain, 18 ABVD (combination chemotherapy), 98– 99, 113, 115, 116, 122, 256, 257 Achong, Bert, 344 active immunization, 169 acupressure, 89, 243 acupuncture, 89, 213, 243 acute lymphoblastic leukemia, 110–11, 349 acute lymphoblastic lymphoma. See lymphoblastic lymphoma acyclovir, 204 Adcetris (brentuximab vedotin), 165 adenine, 126, 267, 269 adenoids, 286, 287, 360 adenosine, 118, 123 Adriamycin (“Big Red,” doxorubicin, hydroxydaunomycin ), 56, 72, 98, 99, 107, 112, 113–16, 123, 134 heart damage associated with, 56–57, 93, 115–16, 215, 225, 226, 256–57 for lymphoblastic lymphoma, 111 side effects of, 115–16, 258 adult T-cell leukemia/lymphoma (ATLL), 38, 168, 276, 349–50 AZT for, 113 and HTLV-I, 113, 349–50, 380 Agent Orange, 385 AIDS, lymphomas associated with, 29, 36, 113, 340, 343, 346, 380–82 Air Charity Network, 194 alcohol, 21, 30, 53, 144, 216, 386 and nausea associated with chemotherapy , 89 and procarbazine, 130 alemtuzumab. See CAMPATH1H alendronate (Fosamax), 129 alkaline phosphatase, 55, 56 alkylating agents, 70, 71, 83, 98, 103, 104, 107, 116, 118, 119, 120, 121, 122, 125, 130, 131, 148, 226, 250, 257, 273 alkylation, 71 allopurinol, 45, 113, 158, 159, 160, 217 alopecia. See hair loss alternative therapies, 89, 210, 212, 213, 219, 220, 234, 235, 237, 244 amino acids, 267–68, 274–75 amphotericin, 203 amplification (in DNA replication), 275 anaplastic large cell lymphoma (ALCL), 165, 350–52, 376 anaplastic lymphoma kinase (ALK) enzyme, 351 anaplastic lymphoma kinase (ALK)–positive large B-cell lymphoma, 342 anemia and chemotherapy, 39, 83, 119 of chronic disease, 39 fatigue associated with, 90–91 hemolytic, 38, 39 iron deficiency, 28, 38, 39 and lymphoplasmacytic lymphoma, 331 megaloblastic, 224 U 426 Index microcytic hypochromic, 39 as symptom of lymphoma, 3–8, 21, 354 symptoms of, 39–40 angiodysplasia, 6 angiogenesis, 174, 175 angioimmunoblastic lymphoma (AIL), 352, 353, 376 Ann Arbor B symptoms, 19–21, 22, 30, 98, 167 Ann Arbor staging system, 360–62 antagonists, 86–87 anthracyclines, 70, 72, 107, 111, 113 antiangiogenesis, 174, 175 antibiotics, 74, 78, 82, 105, 167, 190, 241, 335 and chemotherapy, 119, 123, 124, 158 and stem cell transplants, 196, 197, 201, 202, 203–4, 205 antibodies, 41, 152–56, 190, 268, 285, 291, 292, 293, 297, 302, 311, 331 and antigens, 291 chimeric, 156 structure of, 294–95 as used in diagnosis, 26–27, 320 See also immune system; immunoglobulins ; monoclonal antibodies antibody-dependent cellular cytotoxicity, 310 antidepressants, 92, 131 antiemetic agents, 86–88, 122, 142, 146 antigenic determinants, 291, 300 antigens, 152–53, 170–71, 290, 293, 295, 335, 390–91 and B-cell function, 175–76, 177, 290– 92, 296–302, 311 and T-cell function, 306–8, 311 See also human leukocyte antigens antimetabolites, 70 antimitotics, 70, 72–73, 107, 131 antineoplastic drugs, 69–73, 111, 114 administering of, 94–95 for very aggressive lymphomas, 111–12 See also chemotherapy antioxidants, 115, 222–24, 225–27 antisense gene therapy, 171–73 apheresis, 191 apoptosis, 70, 72, 153, 172, 173, 278, 279, 297, 301, 306, 333, 375, 378 appendix, 286 Aranesp, 83 Arzerra. See ofatumumab Aspergillus, 203 astragalus, 240, 244 Ativan, 86 atovaquone, 204 augmerosen (Genasense), 173 autoimmune disease, 297, 335, 354, 390– 91 autonomic nervous system, 229–30, 231 Avena, Thomas, 133–34 AZT (zidovudine), 113 band cells, 34 Barr, Yvonne, 344 basophils, 34, 82, 282, 283, 284 B-cell lymphomas, 107, 113, 154, 297, 325–46 and antisense gene therapy, 172–73 classification of, 321, 322 and cytokine balance, 167 proteins associated with, 154, 155 rituximab as treatment for, 156–57, 159, 319 See also specific types of B‑cell lymphoma B-cell lymphopoiesis, 292 B-cell mitogen, 240, 298 B-cell receptors, 175–76, 177, 296–98, 329, 383, 390, 391 B cells, 268, 285, 286, 288, 307 activation of, 175–76, 177, 297–300, 310–11 and antigen binding, 175–76, 177, 290–92 development of, 292–96, 303 follicular, 300–301, 304 and helper T cells, 298–300 immunopoiesis, 292, 297 and lymphoma vaccines, 169 lymphopoiesis, 292, 305 naive, 297, 311 anemia (continued) Index 427 V and pokeweed mitogen, 240 in the thymus, 309–10 BCL2 antisense, 173 BCL2 gene, 172–73, 279, 333, 345 BCL2 protein, 172–73, 333, 378 BCL6 gene, 339 BCNU (carmustine), 71, 105, 111, 116 BEACOPP (combination chemotherapy), 99, 128, 256 BEAM (combination chemotherapy), 126 Becquerel, A. Henri, 49 Behring, Emil von, 285–86 bendamustine, 116 benzene, 385 beta-carotene (β-carotene), 222–23 Bexxar (tositumomab), 163, 164 biofeedback devices, 231 biopsies, 17...