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A Machine to Make a Future represents a remarkably original look at the present and possible future of biotechnology research in the wake of the mapping of the human genome. The central tenet of Celera Diagnostics--the California biotech company whose formative work during 2003 is the focus of the book--is that the emergent knowledge about the genome, with its profound implications for human health, can now be turned into a powerful diagnostic apparatus--one that will yield breakthrough diagnostic and therapeutic products (and, potentially, profit). Celera's efforts--assuming they succeed--may fundamentally reshape the fabric of how health and health care are understood, practiced, and managed.
Presenting a series of interviews with all of the key players in Celera Diagnostics, Paul Rabinow and Talia Dan-Cohen open a fascinating window on the complexity of corporate scientific innovation. This marks a radical departure from other books on the biotech industry by chronicling the vicissitudes of a project during a finite time period, in the words of the actors themselves.
Ultimately, the authors conclude, Celera Diagnostics is engaged in a future characterized not by geniuses and their celebrated discoveries but by a largely anonymous and widely distributed profusion of data and results--a "machine to make a future."
In their new afterword, Rabinow and Dan-Cohen revisit Celera Diagnostics as its mighty machine grinds along, wondering, along with the scientists, "what constitutes success and what constitutes failure?" The pathos of the situation turns on how one poses the question as much as how one answers it.
In this follow up to his book, The Rule of Racialization—which considered the way class structure is formed in the U.S.—Steve Martinot now examines how the structures of racialization reside at the core of all social, cultural, and political institutions in the U.S. In The Machinery of Whiteness, Martinot examines how race and racism are produced in the United States, analyzing the politics of racialization, and the preponderance of racial segregation and racial deprivation that have kept the U.S. a white dominated society throughout its history. Martinot dedicates this work to expunging white supremacy from the earth.
The Machinery of Whiteness investigates how “whiteness” came to be as foundational to the process that then produced the modern concept of race. Martinot addresses the instrumentalization of women as a necessary step in its formation, furthering the debates regarding the relationships of race and gender. And he addresses U.S. international interventionism, the anti-immigrant movements, and white racist populism to describe the political forms that white supremacy takes.
Martinot puts these together to analyze the underlying cultural structures of racialization that have driven and conditioned the resurgence of white supremacy and white entitlement in the wake of the Civil Rights movements. This book is a call to transform the cultural structures of the U.S. to make justice and democracy, which depend on inclusion and not segregation, possible.
The Cardiac Pacemaker, the Implantable Defibrillator, and American Health Care
Today hundreds of thousands of Americans carry pacemakers and implantable cardioverter-defibrillators (ICDs) within their bodies. These battery-powered machines—small computers, in fact—deliver electricity to the heart to correct dangerous disorders of the heartbeat. But few doctors, patients, or scholars know the history of these devices or how "heart-rhythm management" evolved into a multi-billion-dollar manufacturing and service industry. Machines in Our Hearts tells the story of these two implantable medical devices. Kirk Jeffrey, a historian of science and technology, traces the development of knowledge about the human heartbeat and follows surgeons, cardiologists, and engineers as they invent and test a variety of electronic devices. Numerous small manufacturing firms jumped into pacemaker production but eventually fell by the wayside, leaving only three American companies in the business today. Jeffrey profiles pioneering heart surgeons, inventors from the realms of engineering and medical research, and business leaders who built heart-rhythm management into an industry with thousands of employees and annual revenues in the hundreds of millions. As Jeffrey shows, the pacemaker (first implanted in 1958) and the ICD (1980) embody a paradox of high-tech health care: these technologies are effective and reliable but add billions to the nation's medical bill because of the huge growth in the number of patients who depend on implanted devices to manage their heartbeats.
Scientist, Progressive Educator, Radical Philanthropist
Maclure of New Harmony follows the twists and turns of William Maclure's intriguing life. A native Scotsman, Maclure (1763--1840) became a merchant, made a fortune, and retired in his early thirties. Then his life became interesting. Fascinated by the study of geology, Maclure did fieldwork throughout Europe before traveling to the United States, where he completed the first geological survey of his adopted nation and published a detailed, color geological map -- one reason he is known as the Father of American Geology.
Maclure's travels sharpened his convictions about social justice and led him to a life of social radicalism. He founded progressive schools to educate the children of the working classes and, in 1820, he joined forces with Robert Owen to found New Harmony -- the utopian community in Indiana. Ever restless, Maclure later moved to Mexico, where he watched his hopes for the new republic founder.
Digital Methods and Literary History
In this volume, Matthew L. Jockers introduces readers to large-scale literary computing and the revolutionary potential of macroanalysis--a new approach to the study of the literary record designed for probing the digital-textual world as it exists today, in digital form and in large quantities. Using computational analysis to retrieve key words, phrases, and linguistic patterns across thousands of texts in digital libraries, researchers can draw conclusions based on quantifiable evidence regarding how literary trends are employed over time, across periods, within regions, or within demographic groups, as well as how cultural, historical, and societal linkages may bind individual authors, texts, and genres into an aggregate literary culture.
Moving beyond the limitations of literary interpretation based on the "close-reading" of individual works, Jockers describes how this new method of studying large collections of digital material can help us to better understand and contextualize the individual works within those collections.
How do public laws, treaties, Senate confirmations, and other legislative achievements help us to gain insight into how our governmental system performs?
This well-argued book edited by Scott Adler and John Lapinski is the first to assess our political institutions by looking at what the authors refer to as legislative accomplishment. The book moves beyond current research on Congress that focuses primarily on rules, internal structure, and the microbehavior of individual lawmakers, to look at the mechanisms that govern how policy is enacted and implemented in the United States. It includes essays on topics ranging from those dealing with the microfoundations of congressional output, to large N empirical analyses that assess current theories of lawmaking, to policy-centered case studies.
All of the chapters take a Congress-centered perspective on macropolicy while still appreciating the importance of other branches of government in explaining policy accomplishment. The Macropolitics of Congress shines light on promising pathways for the exploration of such key issues as the nature of political representation. It will make a significant contribution to the study of Congress and, more generally, to our understanding of American politics. Contributors include E. Scott Adler, David Brady, Charles M. Cameron, Brandice Canes-Wrone, Robert S. Erikson, Grace R. Freedman, Valerie Heitshusen, John D. Huber, Ira Katznelson, Keith Krehbiel, John S. Lapinski, David Leblang, Michael B. MacKuen, David R. Mayhew, Nolan McCarty, Charles R. Shipan, James A. Stimson, and Garry Young.
Rhetorics of Mental Disability and Academic Life
A very important study that will appeal to a disability studies audience as well as scholars in social movements, social justice, critical pedagogy, literacy education, professional development for disability and learning specialists in access centers and student counseling centers, as well as the broader domains of sociology and education. ---Melanie Panitch, Ryerson University "Ableism is alive and well in higher education. We do not know how to abandon the myth of the 'pure (ivory) tower that props up and is propped up by ableist ideology.' . . . Mad at School is thoroughly researched and pathbreaking. . . . The author's presentation of her own experience with mental illness is woven throughout the text with candor and eloquence." ---Linda Ware, State University of New York at Geneseo Mad at School explores the contested boundaries between disability, illness, and mental illness in the setting of U.S. higher education. Much of the research and teaching within disability studies assumes a disabled body but a rational and energetic (an "agile") mind. In Mad at School, scholar and disabilities activist Margaret Price asks: How might our education practices change if we understood disability to incorporate the disabled mind? Mental disability (more often called "mental illness") is a topic of fast-growing interest in all spheres of American culture, including popular, governmental, aesthetic, and academic. Mad at School is a close study of the ways that mental disabilities impact academic culture. Investigating spaces including classrooms, faculty meeting rooms, and job searches, Price challenges her readers to reconsider long-held values of academic life, including productivity, participation, security, and independence. Ultimately, she argues that academic discourse both produces and is produced by a tacitly privileged "able mind," and that U.S. higher education would benefit from practices that create a more accessible academic world. Mad at School is the first book to use a disability-studies perspective to focus specifically on the ways that mental disabilities impact academic culture at institutions of higher education. Individual chapters examine the language used to denote mental disability; the role of "participation" and "presence" in student learning; the role of "collegiality" in faculty work; the controversy over "security" and free speech that has arisen in the wake of recent school shootings; and the marginalized status of independent scholars with mental disabilities. Margaret Price is Associate Professor of English at Spelman College.
A History of Resurgent Rabies in Southern Africa
In South Africa, rabies has been on the rise since the latter part of the twentieth century despite the availability of postexposure vaccines and regular inoculation campaigns for dogs. In Mad Dogs and Meerkats: A History of Resurgent Rabies in Southern Africa, Karen Brown links the increase of rabies to the HIV/AIDS epidemic. Her study shows that the most afflicted regions of South Africa have seen a dangerous rise in feral dog populations as people lack the education, means, or will to care for their pets or take them to inoculation centers. Most victims are poor black children. Ineffective disease control, which in part depends on management policies in neighboring states and the diminished medical and veterinary infrastructures in Zimbabwe, has exacerbated the problem.
This highly readable book is the first study of rabies in Africa, tracing its history in South Africa and neighboring states from 1800 to the present and showing how environmental and economic changes brought about by European colonialism and global trade have had long-term effects.
Mad Dogs and Meerkats is recommended for public health policy makers and anyone interested in human-animal relations and how societies and governments have reacted to one of the world’s most feared diseases.
The Final Testament of a Huichol Messiah from Northwest Mexico
This is the story of an anthropologist's encounter with a Huichol Indian known as "Mad Jesus." Jesús was an artisan, a shaman, a self-styled prophet, a mad messiah, and a murderous mystic. Timothy J. Knab was a young anthropologist soliciting life histories from Huichols in Mexico City when they met. The life story of Jesús may have been the ravings of a madman, but it also embodied the Huichol anticipation of the return of Santo Cristo, the savior who will restore the Huichol to their place as masters of the world around them. Neither Knab's studies in anthropology nor his experiences in the world of counterculture prepared him to understand this strange Indian and his violent history and behavior.