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Reform, Resistance, and the Pursuit of a Rational Therapeutics
In The Antibiotic Era, physician-historian Scott H. Podolsky narrates the far-reaching history of antibiotics, focusing particularly on reform efforts that attempted to fundamentally change how antibiotics are developed and prescribed. This sweeping chronicle reveals the struggles faced by crusading reformers from the 1940s onward as they advocated for a rational therapeutics at the crowded intersection of bugs and drugs, patients and doctors, industry and medical academia, and government and the media. During the post–World War II “wonder drug” revolution, antibiotics were viewed as a panacea for mastering infectious disease. But from the beginning, critics raised concerns about irrational usage and overprescription. The first generation of antibiotic reformers focused on regulating the drug industry. The reforms they set in motion included the adoption of controlled clinical trials as the ultimate arbiters of therapeutic efficacy, the passage of the Kefauver-Harris amendments mandating proof of drug efficacy via well-controlled studies, and the empowering of the Food and Drug Administration to remove inefficacious drugs from the market. Despite such victories, no entity was empowered to rein in physicians who inappropriately prescribed, or overly prescribed, approved drugs. Now, in an era of emerging bugs and receding drugs, discussions of antibiotic resistance focus on the need to develop novel antibiotics and the need for more appropriate prescription practices in the face of pharmaceutical marketing, pressure from patients, and the structural constraints that impede rational delivery of antibiotics worldwide. Concerns about the enduring utility of antibiotics—indeed, about a post-antibiotic era—are widespread, as evidenced by reports from the Centers for Disease Control and Prevention, academia, and popular media alike. Only by understanding the historical forces that have shaped our current situation, Podolsky argues, can we properly understand and frame our choices moving forward.
Or, The Sources of His Quantitative Method in Chemistry
Through his development of quantitative experimental methods, the chemist Antoine Lavoisier (1743-1794) implemented a principle that many regard as the cornerstone of modern science: in every operation there is an equal quantity of material before and after the operation. The origin of Lavoisier's methods, however, has remained a missing piece in this remarkable episode of scientific history, perhaps because the talented young scientist himself was not prepared for the journey his discoveries would set before him. In this book, Frederic Holmes suggests that Lavoisier gradually came to understand the nature and power of his quantitative method during the year 1773, when he began to carry out a research program on the fixation and release of airs. Drawing upon Lavoisier's surviving laboratory notebooks, Holmes presents an engaging portrait of a scientist still seeking the way that would lead him to become the leader of one of the great upheavals in the history of science.
Holmes follows Lavoisier day-by-day at work in his laboratory over a course of several months. The scientist's resourcefulness and imagination spring to life in this account, as does his propensity to make mistakes, which taught him as much as his successes. During the course of this odyssey, Lavoisier saw his early theory of combustion collapse under the weight of his own efforts to provide experimental evidence to support it. In compensation, he acquired a method and the hard-won experience on which he would later construct a more enduring theoretical structure.
Originally published in 1997.
The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These paperback editions preserve the original texts of these important books while presenting them in durable paperback editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
A Short History
More people today report feeling anxious than ever before—even while living in relatively safe and prosperous modern societies. Almost one in five people experiences an anxiety disorder each year, and more than a quarter of the population admits to an anxiety condition at some point in their lives. Here Allan V. Horwitz, a sociologist of mental illness and mental health, narrates how this condition has been experienced, understood, and treated through the ages—from Hippocrates, through Freud, to today. Anxiety is rooted in an ancient part of the brain, and our ability to be anxious is inherited from species far more ancient than humans. Anxiety is often adaptive: it enables us to respond to threats. But when normal fear yields to what psychiatry categorizes as anxiety disorders, it becomes maladaptive. As Horwitz explores the history and multiple identities of anxiety—melancholia, nerves, neuroses, phobias, and so on—it becomes clear that every age has had its own anxieties and that culture plays a role in shaping how anxiety is expressed.
The great mathematician Archimedes, a Sicilian Greek whose machines defended Syracuse against the Romans during the Second Punic War, was killed by a Roman after the city fell, yet it is largely Roman sources, and Greek texts aimed at Roman audiences, that preserve the stories about him. Archimedes' story, Mary Jaeger argues, thus becomes a locus where writers explore the intersection of Greek and Roman culture, and as such it plays an important role in Roman self-definition. Jaeger uses the biography of Archimedes as a hermeneutic tool, providing insight into the construction of the traditional historical narrative about the Roman conquest of the Greek world and the Greek cultural invasion of Rome. By breaking down the narrative of Archimedes' life and examining how the various anecdotes that comprise it are embedded in their contexts, the book offers fresh readings of passages from both well-known and less-studied authors, including Polybius, Cicero, Livy, Vitruvius, Plutarch, Silius Italicus, Valerius Maximus, Johannes Tzetzes, and Petrarch. "Jaeger, in her meticulous and elegant study of different ancient accounts of his life and inventions...reveal more about how the Romans thought about their conquest of the Greek world than about 'science'." ---Helen King, Times Literary Supplement "An absolutely wonderful book on a truly original and important topic. As Jaeger explores neglected texts that together tell an important story about the Romans' views of empire and their relationship to Greek cultural accomplishments, so she has written an important new chapter in the history of science. A genuine pleasure to read, from first page to last." ---Andrew Feldherr, Associate Professor of Classics, Princeton University "This elegantly written and convincingly argued project analyzes Archimedes as a vehicle for reception of the Classics, as a figure for loss and recovery of cultural memory, and as a metaphorical representation of the development of Roman identity. Jaeger's fastening on the still relatively obscure figure of the greatest ancient mathematician as a way of understanding cultural liminality in the ancient world is nothing short of a stroke of genius." ---Christina S. Kraus, Professor and Chair of Classics, Yale University "Archimedes and the Roman Imagination forms a useful addition to our understanding of Roman culture as well as of the reception of science in antiquity. It will make a genuine contribution to the discipline, not only in terms of its original interpretative claims but also as a fascinating example of how we may follow the cultural reception of historical figures." ---Reviel Netz, Professor of Classics, Stanford University Cover art: Benjamin West. Cicero Discovering the Tomb of Archimedes. Yale University Art Gallery. John Hill Morgan, B.A. 1893, LL.B. 1898, M.A. (Hon.) 1929, Fund.
Cochlear Implants and the Culture of Deafness
Part ethnography and part historical study, The Artificial Ear is based on interviews with researchers who were pivotal in the early development and implementation of the new technology necessary for cochlear implants. Through an analysis of the scientific and clinical literature, Stuart Blume reconstructs the history of artificial hearing from its conceptual origins in the 1930s, to the first attempt at cochlear implantation in Paris in the 1950s, and to the widespread clinical application of the "bionic ear" since the 1980s.
This book provides the historical background for a central issue in the history of science: the influence of artisans, craftsmen, and other practitioners on the emergent empirical methodologies that characterized the “new sciences” of the late sixteenth and seventeenth centuries. Long offers a coherent account and critical revision of the “Zilsel thesis,” an influential etiological narrative which argues that such craftsmen were instrumental in bringing about the “Scientific Revolution.”
Artisan/Practitioners reassesses the issue of artisanal influence from three different perspectives: the perceived relationships between art and nature; the Vitruvian architectural tradition with its appreciation of both theory and practice; and the development of “trading zones”—arenas in which artisans and learned men communicated in substantive ways. These complex social and intellectual developments, the book argues, underlay the development of the empirical sciences.
This volume provides new discussion and synthesis of a theory that encompasses broad developments in European history and study of the natural world. It will be a valuable resource for college-level teaching, and for scholars and others interested in the history of science, late medieval and early modern European history, and the Scientific Revolution.
Technological Tradeoffs and the Body at Risk
For much of the industrial era, asbestos was a widely acclaimed benchmark material. During its heyday, it was manufactured into nearly three thousand different products, most of which protected life and property from heat, flame, and electricity. It was used in virtually every industry from hotel keeping to military technology to chemical manufacturing, and was integral to building construction from shacks to skyscrapers in every community across the United States. Beginning in the mid-1960s, however, this once popular mineral began a rapid fall from grace as growing attention to the serious health risks associated with it began to overshadow the protections and benefits it provided.
In this thought-provoking and controversial book, Rachel Maines challenges the recent vilification of asbestos by providing a historical perspective on Americans’ changing perceptions about risk. She suggests that the very success of asbestos and other fire-prevention technologies in containing deadly blazes has led to a sort of historical amnesia about the very risks they were supposed to reduce.
Asbestos and Fire is not only the most thoroughly researched and balanced look at the history of asbestos, it is also an important contribution to a larger debate that considers how the risks of technological solutions should be evaluated. As technology offers us ever-increasing opportunities to protect and prevent, Maines urges that learning to accept and effectively address the unintended consequences of technological innovations is a growing part of our collective responsibility.
This book offers an informed and revealing account of NASA’s involvement in the scientific understanding of the Earth’s atmosphere. Since the nineteenth century, scientists have attempted to understand the complex processes of the Earth’s atmosphere and the weather created within it. This effort has evolved with the development of new technologies—from the first instrument-equipped weather balloons to multibillion-dollar meteorological satellite and planetary science programs. Erik M. Conway chronicles the history of atmospheric science at NASA, tracing the story from its beginnings in 1958, the International Geophysical Year, through to the present, focusing on NASA’s programs and research in meteorology, stratospheric ozone depletion, and planetary climates and global warming. But the story is not only a scientific one. NASA’s researchers operated within an often politically contentious environment. Although environmental issues garnered strong public and political support in the 1970s, the following decades saw increased opposition to environmentalism as a threat to free market capitalism. Atmospheric Science at NASA critically examines this politically controversial science, dissecting the often convoluted roles, motives, and relationships of the various institutional actors involved—among them NASA, congressional appropriation committees, government weather and climate bureaus, and the military.
Technology and Expertise in Twentieth-Century America
The history of automobiles is not just the story of invention, manufacturing, and marketing; it is also a story of repair. Auto Mechanics opens the repair shop to historical study—for the first time—by tracing the emergence of a dirty, difficult, and important profession. Kevin L. Borg's study spans a century of automotive technology—from the horseless carriage of the late nineteenth century to the "check engine" light of the late twentieth. Drawing from a diverse body of source material, Borg explores how the mechanic’s occupation formed and evolved within the context of broad American fault lines of class, race, and gender and how vocational education entwined these tensions around the mechanic’s unique expertise. He further shows how aspects of the consumer rights and environmental movements, as well as the design of automotive electronics, reflected and challenged the social identity and expertise of the mechanic. In the history of the American auto mechanic, Borg finds the origins of a persistent anxiety that even today accompanies the prospect of taking one's car in for repair.
A Study in Comparative Political Economy
Aviation performance is an important cog in modern globalized economies, which demand flexibility, mobility, efficiency, and dependability. Airport delays have gone from being a nuisance to being a salient public concern, drawing the ire of even the White House. In this important book, international transportation experts compare and contrast how different nations have managed their airports and air traffic control systems and how well they are meeting the needs of their people. The book's cross-national approach encompasses several different institutional arrangements, making it a timely and valuable study in comparative political economy. Among the countries studied, the United States is sometimes seen as a bastion of free markets, at the forefront of airline deregulation, but its airports and air traffic control system are publicly owned and operated. The same is true in continental Europe, for the most part. In contrast, Australia, New Zealand, the United Kingdom, and Canada are experimenting with privatization, while even mainland China is allowing the private sector to participate in airport ownership. Which methods work best, and under what circumstances? This book provides the answers.