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In the decade since the first edition of The Neurobiology of Autism was published, research has revealed valuable new information about the nature and origins of autism, including genetics and abnormalities in such neurotransmitters as acetylcholine and serotonin. For this long-anticipated new edition, neurologists Margaret L. Bauman and Thomas L. Kemper bring together leading researchers and clinicians to present the most current scientific knowledge and theories about autism. The contributors cover genetics, imaging studies, physiology, neuroanatomy and neurochemistry, immunology, brain function, the epidemiology of the disease, and related disorders. Thoroughly updated, The Neurobiology of Autism remains the best single-volume work on the wide array of research being conducted into the causes, characteristics, and treatment of autism.Contributors: George M. Anderson, Yale Child Study Center; Tara L. Arndt, University of Rochester Medical Center (URMC); Trang Au, University of Massachusetts Medical School (UMMC); Jocelyne Bachevalier, University of Texas Health Science Center; Irina N. Bespalova, Seaver Autism Research Center, Mt. Sinai School of Medicine (SARC); Gene J. Blatt, Boston University School of Medicine (BUSM); Susan E. Bryson, IWK Health Centre–Dalhousie University; Timothy M. Buie, Massachusetts General Hospital (MGH); Joseph D. Buxbaum, SARC; Kathryn M. Carbone, The Johns Hopkins University School of Medicine (JHUSM); Diane C. Chugani, Wayne State University; Daniel F. Connor, UMMC; Edwin H. Cook, Jr., University of Chicago; S. Hossein Fatemi, University of Minnesota Medical School; Susan E. Folstein, Tufts University School of Medicine; Eric Fombonne, McGill University; Randi Jenssen Hagerman, UC Davis Medical Center; Elizabeth Petri Henske, Fox Chase Cancer Center, Philadelphia; Jeannette J. A. Holden, Queen's University; Ronald J. Killiany, BUSM; Omanand Koul, UMMC; Mandy Lee, Newcastle General Hospital, U.K.; Xudong Liu, Queen's University; Tara L. Moore, BUSM; Mark B. Moss, BUSM; Karin B. Nelson, National Institute of Neurological Disorders and Stroke; Phillip G. Nelson, National Institute of Child Health and Human Development; Elaine Perry, Newcastle General Hospital; Jonathan Pevsner, JHUSM; Mikhail V. Pletnikov, JHUSM; Stephen W. Porges, University of Illinois at Chicago; Lucio Rehbein, Universidad de la Frontera, Chile; Jennifer Reichert, SARC; Patricia M. Rodier, URMC; Beth Rosen-Sheidley, MGH; Susan L. Smalley, UCLA Neuropsychiatric Research Institute; Ronald J. Steingard, UMMC; Helen Tager-Flusberg, BUSM; Gary L. Wenk, University of Arizona; Andrew W. Zimmerman, JHUSM

Table of Contents

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  1. Cover
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  1. Frontmatter
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  1. Contents
  2. pp. v-vii
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  1. List of Contributors
  2. pp. ix-xi
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  1. Preface
  2. p. xiii
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  1. I: CLINICAL OBSERVATIONS
  1. 1. The Epidemiology of Pervasive Developmental Disorders
  2. pp. 3-22
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  1. 2. Size of the Head and Brain in Autism: Clue to Underlying Biologic Mechanisms?
  2. pp. 23-33
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  1. 3. The Autistic Mind
  2. pp. 34-44
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  1. 4. Language and Communication Disorders in Autism Spectrum Disorders
  2. pp. 45-58
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  1. 5. Memory and Executive Functions in Autism
  2. pp. 59-64
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  1. 6. The Vagus: A Mediator of Behavioral and Physiologic Features Associated with Autism
  2. pp. 65-78
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  1. 7. Approaches to Psychopharmacology
  2. pp. 79-102
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  1. 8. Gastrointestinal Issues Encountered in Autism
  2. pp. 103-117
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  1. II: NEUROANATOMIC INVESTIGATIONS
  1. 9. Structural Brain Anatomy in Autism: What Is the Evidence?
  2. pp. 121-135
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  1. 10. The Brainstem in Autism
  2. pp. 136-149
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  1. 11. Myelin and Autism
  2. pp. 150-163
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  1. 12. Positron Emission Tomography Studies of Autism
  2. pp. 164-176
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  1. 13. The Orbitofrontal-Amygdala System in Nonhuman Primates: Function, Development, and Early Insult
  2. pp. 177-189
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  1. 14. An Animal Model of Virus-Induced Autism: Borna Disease Virus Infection of the Neonatal Rat
  2. pp. 190-203
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  1. III: GENETIC INITIATIVES
  1. 15. Gene Expression in Autism
  2. pp. 207-216
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  1. 16. Candidate Susceptibility Genes for Autism
  2. pp. 217-232
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  1. 17. Chromosome 15 and Autism
  2. pp. 233-241
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  1. 18. Chromosome 7
  2. pp. 242-250
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  1. 19. Fragile X Syndrome
  2. pp. 251-264
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  1. 20. Autism and Tuberous Sclerosis Complex
  2. pp. 265-275
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  1. 21. The Roles of Dopamine and Norepinephrine in Autism: From Behavior and Pharmacotherapy to Genetics
  2. pp. 276-299
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  1. IV: NEUROBIOLOGIC RESEARCH
  1. 22. Serotonin in Autism
  2. pp. 303-318
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  1. 23 The GABAergic System in Autism
  2. pp. 319-330
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  1. 24. The Cholinergic System in Autism
  2. pp. 331-348
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  1. 25. The Role of Reelin in Autism
  2. pp. 349-361
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  1. 26. Brain-Derived Neurotrophic Factor and Dopamine in Autism
  2. pp. 362-370
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  1. 27. The Immune System
  2. pp. 371-386
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  1. Epilogue
  2. pp. 387-391
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  1. Index
  2. pp. 393-404
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