Cover

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pp. 1-3

Title Page

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pp. 4-4

Copyright Page

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pp. 5-5

Dedication Page

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pp. 6-7

Table of Contents

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pp. 8-9

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Preface

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pp. ix-xv

The seemingly unlimited reach of powerful biotechnologies, and the attendant growth of the multi-billion-dollar industry, have raised difficult questions about the scientific discoveries, political assumptions, and cultural patterns that gave rise to for-profit biological research. Given ...

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1: The Setting, 1946

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pp. 1-7

The San Francisco Bay Area, with its own history of scientific successes and its emerging presence at the edge of a technological revolution, had established itself by the end of World War II as a preeminent research center. Here, some critical discoveries had occurred, particularly in ...

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2: Patronage and Policy

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pp. 8-29

Whether celebrated as saviors or scorned as meddlers, patrons of science play a major role in shaping research and influencing its pace and direction. Yet too much can be made of scientific patronage as a cause of discovery. Scientists do not always conduct their experiments in ...

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3: The Promise and Peril of the BVL

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pp. 30-48

When Wendell Stanley arrived at Berkeley in 1948 as head of the biochemistry department and Virus Laboratory, his new colleagues welcomed him by urging everyone-staff, students, and the community-to "offer their complete support." But Stanley did not need any more accoutrements of power to direct a high-powered research...

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4: The Ascent of Pure Research

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pp. 49-98

The experience of Berkeley and the BVL only partly explains the rise of pure research in Bay Area bioscience laboratories. To review, pure research at the BVL forged ahead because the federal government allowed Stanley to establish standards of eligibility and payment. Stanley ...

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5: Research Life!

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pp. 99-128

When the 1960s began, at a time when fundamental research questions seemed to dominate the biological sciences at all three Bay Area research universities, a quiet opposition began to question the perceived value of pure knowledge, the federal government's blanket support of research, and the isolation of biology ...

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6: A Season of Policy Reform

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pp. 129-156

The making of a biotechnology industry involved both the loosening of the scientific research agenda through conflict between pure and applied researchers as well as a counter culture that raised challenging questions about the value of pure research. Indeed, the precondition for the coming revolution was this rare combination in which ...

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7: Crossing the Threshold

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pp. 157-185

By the end of the 1960s, the overriding issue in the biological sciences had become the practical application of pure knowledge. The popular wish for utility had become the preferred answer for bioscience research, draining fundamental discovery of its experimental ...

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8: Cetus: History's First Biotechnology Company

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pp. 186-227

The first biotechnology company started with a machine. Not just any machine; it was a bioengineering machine. It could induce mutations in a massive vat of organisms. It could identify strains for potency, reproducibility, morphology. It could make clones. No one at the beginning ...

Notes

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pp. 229-265

Sources Consulted

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pp. 267-268

Index

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pp. 286-290