A provocative survey of interdisciplinary challenges to the concept of determinism. During the last few decades, the fundamental premises of the modern view of knowledge have been increasingly called into question. Questioning Nineteenth-Century Assumptions about Knowledge I: Determinism provides an in-depth look at the debates surrounding the status of “determinism” in the sciences, social sciences, and the humanities in detailed and wide-ranging discussions among experts from across the disciplines. A concern for the future, and how to approach it, is evident throughout. Indeed, the sense that there exists a reciprocal relationship between the structures of knowledge and human systems, including ecosystems, suggests that thinking about the possible rather than the necessary, may be a more winning strategy for our times. Weaving together in-depth articles and invigorating follow up discussions, this volume showcases debates over the status and validity of determinism. Of special interest are the impact of determinism on the perception and writing about the past; the relationship between chance and necessity in philosophy and grand opera; and the affect of determinism in mathematical modeling and economics.