This article reports on two art-science collaborations, A-me: Augmented Memories and BrainCloud, that interrogate the central role of localization in neuroscience—including the use of technologies that augment sociability using localization as a central reference point. The two projects result from a series of interactions where a science/ technology development fostered art, which in turn led to a science application, which potentially may lead to further artistic activity. A-me is an art installation that repurposes navigation and visualization tools normally reserved for medical clinicians and scientists, inviting reflection on the ongoing endeavor of neuroscience to explain and map cognitive functions such as memory. BrainCloud is a software prototype that provides neuroscientists with an interface for interacting with existing data and knowledge about the brain. Organized visually as a brain atlas, it forms a social network that allows neuroscientists to connect and share their ongoing research and ideas.