There have been important changes in the politics of the eastern Mediterranean since the discovery of energy resources and the disintegration of Turkish-Israeli relations. Israel upgraded its relationship with Greece and Cyprus after its ties with Turkey deteriorated. Since shortly after the 2010 Mavi Marmara incident, the widening divergence in interests between Turkey and Israel have provided the geopolitical impetus for the development of a rapprochement between Greece and Israel. While political, military, and economic cooperation, in particular, between Israel and Greece have significantly developed, the relations have also blossomed over mutual concern about the energy resources in the eastern Mediterranean. This essay examines the burgeoning relationship between Israel and Greece since 2010 and considers whether this relationship constitutes an important strategic alliance in the eastern Mediterranean.