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Background. The relationship between behavioral problems and obesity in early childhood in Latinos is largely unknown. Methods. Cross-sectional anthropometric and behavioral data of children at three years of age were gathered from a cohort of 174 children of Latina mothers at two San Francisco hospitals. Child behaviors were assessed using the preschool Child Behavior Checklist (CBCL/1½–5). Logistic regression was used to analyze the association between behavior and obesity. Results. At three years, 27.7% were obese. There were no associations between affective (OR = 1.89; 95% confidence interval [CI] 0.42–8.59), anxiety (OR = 1.86; 95% CI 0.53–6.47), pervasive developmental (OR = 0.42; 95% CI 0.13–1.36), attention deficit hyperactivity (OR = 0.58; 95% CI 0.12–2.76), or oppositional defiant (OR = 6.49; 95% CI 0.65–64.49) problems and obesity. Conclusions. Though psychological problems and obesity are associated among older children and adolescents, there was no association in Latino three-year olds in a low-income sample.