Racial microaggressions are subtle (often unintentional or unconscious) forms of racial discrimination that negatively affect victims’ mental health. Utilizing an undergraduate student sample (N = 225), the current study examined the relationship between racial microaggressions and self-esteem. Results indicate that racial microaggressions negatively predict a lower self-esteem, and that microaggressions that occur in educational and workplace environments are particularly harmful to self-esteem. Finally, findings reveal that individuals of various racial and ethnic minority groups experience racial microaggressions differently. Implications for student development and recommendations for further research involving racial microaggressions and college students are discussed.