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Lack of Arg972 Polymorphism in the IRS1 Gene in Parakana Brazilian Indians

From: Human Biology
Volume 76, Number 1, February 2004
pp. 147-151 | 10.1353/hub.2004.0015

Abstract

Several polymorphisms in the insulin receptor substrate-1 (IRS1) gene have been reported in the last years. The most common IRS1 variant, a Gly[epV[rsArg substitution at codon 972 (Arg972 IRS1), is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations. To determine whether the absence of IRS1 polymorphism is a more general characteristic of Paleo-Indian-derived populations, we examined the Arg972 IRS1 polymorphism in Parakanã Indians and found a lack of this polymorphism in the Parakanã population.