Key Concepts: Endophenotypes

Endophenotypes are an exciting and important area of research in genetically complex psychiatric diseases. They are biological markers between genotype and external phenotype that may indicate susceptibility to or manifest as early signs of a wide range of mental disorders. Identifying endophenotypes can enable researchers to tease apart the biological components of psychiatric diseases and thereby gain a better understanding of them. They may lead to more accurate prediction and to more effective prevention and treatment. Endophenotypes also have implications for the philosophy of mind and the ethics of informed consent.